Akira Nakashima   Yu Kodani   Yoko S. Kaneko   Hiroshi Nagasaki   Akira Ota   
Journal of Neural Transmission 125(1) 9-15 2018年1月 [査読有り]
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. However, the intracellular stability of TH determined by the degra...
Akira Nakashima   Syuhei Ohnuma   Yu Kodani   Yoko S. Kaneko   Hiroshi Nagasaki   Toshiharu Nagatsu   Akira Ota   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 472(4) 598-602 2016年4月 [査読有り]
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. However, the intracellular stability determined by the degradation...
Yoko S. Kaneko   Takeshi Takayanagi   Hiroshi Nagasaki   Yu Kodani   Akira Nakashima   Keiji Mori   Atsushi Suzuki   Mitsuyasu Itoh   Kazunao Kondo   Toshiharu Nagatsu   Miyuki Ota   Akira Ota   
JOURNAL OF NEURAL TRANSMISSION 122(6) 757-772 2015年6月 [査読有り]
We previously showed that aripiprazole increases intracellular NADPH and glucose-6-phosphate dehydrogenase mRNA in PC12 cells. Aripiprazole presumably activates a system that concurrently detoxifies reactive oxygen species and replenishes NADPH. N...