Akira Nakashima   Akira Ota   Yoko S. Kaneko   Keiji Mori   Hiroshi Nagasaki   Toshiharu Nagatsu   
JOURNAL OF NEURAL TRANSMISSION 120(1) 49-54 2013年1月 [査読有り]
Postmortem brain biochemistry has revealed that the main symptom of movement disorder in Parkinson's disease (PD) is caused by a deficiency in dopamine (DA) at the nerve terminals of degenerating nigro-striatal DA neurons in the striatum. Since ty...
Akira Nakashima   Yoko S. Kaneko   Yu Kodani   Keiji Mori   Hiroshi Nagasaki   Toshiharu Nagatsu   Akira Ota   
Advances in Pharmacology 68 3-11 2013年 [査読有り]
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is a key protein involved in the pathogenesis of neurodegenerative diseases such as Parkinson's disease. Elucidation of the mechanisms regulating the synthe...
Akira Ota   Akira Nakashima   Yoko S. Kaneko   Keiji Mori   Hiroshi Nagasaki   Takeshi Takayanagi   Mitsuyasu Itoh   Kazunao Kondo   Toshiharu Nagatsu   Miyuki Ota   
JOURNAL OF NEURAL TRANSMISSION 119(11) 1327-1342 2012年11月 [査読有り]
Aripiprazole is the only atypical antipsychotic drug known to cause the phosphorylation of AMP-activated protein kinase (AMPK) in PC12 cells. However, the molecular mechanisms underlying this phosphorylation in aripiprazole-treated PC12 cells have...
Keiji Mori   Yoko S. Kaneko   Akira Nakashima   Hiroshi Nagasaki   Toshiharu Nagatsu   Ikuko Nagatsu   Akira Ota   
CELLULAR AND MOLECULAR NEUROBIOLOGY 32(5) 777-785 2012年7月 [査読有り]
This review summarizes the effects of neuroinflammatory stress on the subventricular zone (SVZ), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with Parkinson's disease (PD), because the SVZ i...