Protein phosphorylation, a key regulator of cellular processes, plays a central role in brain function and is implicated in neurological disorders. Information on protein phosphorylation is expected to be a clue for understanding various neuropsyc...
The unraveling of the regulatory mechanisms that govern neuronal excitability is a major challenge for neuroscientists worldwide. Neurotransmitters play a critical role in maintaining the balance between excitatory and inhibitory activity in the b...
Pharmacological research 194 106838-106838 2023年6月
Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic treatment in SCZ improves positive symptoms but has major side effects and little impact on n...
British journal of pharmacology 180(18) 2393-2411 2023年4月
BACKGROUND AND PURPOSE: High salt (HS) intake has been associated with hypertension and cognitive impairment. It is well-known that angiotensin II (Ang II)-AT1 and prostaglandin E2 (PGE2)-EP1 systems are involved in hypertension and neurotoxicity....
Neurochemistry international 162 105438-105438 2023年1月
Dopamine regulates psychomotor function by D1 receptor/PKA-dependent phosphorylation of DARPP-32. DARPP-32, phosphorylated at Thr34 by PKA, inhibits protein phosphatase 1 (PP1), and amplifies the phosphorylation of other PKA/PP1 substrates followi...
BACKGROUND: Postpartum depression (PPD) is a major depressive disorder that occurs after childbirth. Objective diagnostic and predictive methods for PPD are important for early detection and appropriate intervention. DNA methylation has been recog...
Although a number of studies have identified several convincing candidate genes or molecules, the pathophysiology of schizophrenia (SCZ) has not been completely elucidated. Therapeutic optimization based on pathophysiology should be performed as e...
主要組織適合遺伝子複合体クラスI(major histocompatibility complex class I;MHCI)は中枢神経系において主に神経細胞に発現し、スパインの刈り込みなどに関与している。グリア細胞におけるMHCIの病態生理学的役割については不明な点が多いことから、我々は末梢性免疫炎症反応による中枢神経系におけるMHCIの発現変化、ならびに前頭前皮質のアストロサイトにおける膜貫通型MHCI/H-2Dあるいは分泌型MHCI/sH-2Dの発現が周囲の細胞と高次脳機能に及ぼす影...