Kazuhide Watanabe   Matthew J. Meyer   Luigi Strizzi   Joseph M. Lee   Monica Gonzales   Caterina Bianco   Tadahiro Nagaoka   Shahram S. Farid   Naira Margaryan   Mary J. C. Hendrix   Barbara K. Vonderhaar   David S. Salomon   
STEM CELLS 28(8) 1303-1314 2010年8月 [査読有り]
Deregulation of stem cells is associated with the generation and progression of malignant tumors. In addition, genes that are associated with early embryogenesis are frequently expressed in cancer. Cripto-1 (CR-1), a glycosylphosphatidylinositol-l...
Caterina Bianco   Maria Cristina Rangel   Nadia P. Castro   Tadahiro Nagaoka   Kelly Rollman   Monica Gonzales   David S. Salomon   
AMERICAN JOURNAL OF PATHOLOGY 177(2) 532-540 2010年8月 [査読有り]
Cripto-1 is critical for early embryonic development and, together with its ligand Nodal, has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Like other embryonic genes, Cripto-1 performs impor...
Nadia Pereira de Castro   Maria Cristina Rangel   Tadahiro Nagaoka   David S. Salomon   Caterina Bianco   
FUTURE ONCOLOGY 6(7) 1127-1142 2010年7月 [査読有り]
Several studies have shown that cell fate regulation during embryonic development and oncogenic transformation share common regulatory mechanisms and signaling pathways. Indeed, an embryonic gene member of the EGF-Cripto-1/FRL1/Cryptic family, Cri...
The extracellular domains (ECD) of epidermal growth factor receptors, ErbB1, 2, 3 and 4, were designed as soluble dimeric forms. Each ECD was fused to a short hinge region derived from IgG, such that the stable dimer could be formed with disulfide...