The group A rotavirus (RVA) genome comprising 11 double-stranded RNAs encodes six structural proteins (VP1-VP4, VP6, and VP7) and six non-structural proteins (NSP1-NSP6). Among these 12 rotaviral proteins, NSP6 has been less studied as to its func...
Kazuhiro J Fujimoto Daniel C F Hobbs Miki Umeda Akihiro Nagata Rie Yamaguchi Yoshitaka Sato Ayato Sato Kohsuke Ohmatsu Takashi Ooi Takeshi Yanai Hiroshi Kimura Takayuki Murata
Viruses 14(2) 2022年2月
Inhibition of transmembrane serine protease 2 (TMPRSS2) is expected to block the spike protein-mediated fusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nafamostat, a potent TMPRSS2 inhibitor as well as a candidate for anti-...
Epstein-Barr virus (EBV) is an etiologic agent of infectious mononucleosis and several malignancies. Here, we found that reactivation of EBV resulted in increased programmed cell death-ligand 1 (PD-L1) expression in a cell type-dependent manner. L...
N6-methyladenosine (m6A) mediates various biological processes by affecting RNA stability, splicing, and translational efficiency. The roles of m6A modification in Epstein-Barr virus (EBV) infection in the lytic phase are unclear. Here, knockout o...
Ernest Apondi Wandera Riona Hatazawa Naohisa Tsutsui Natsuki Kurokawa Cyrus Kathiiko Maurine Mumo Eunice Waithira Mary Wachira Boniface Mwaura James Nyangao Samoel Ashimosi Khamadi Joseph Njau Saori Fukuda Takayuki Murata Koki Taniguchi Yoshio Ichinose Satoshi Kaneko Satoshi Komoto
Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 96 105133-105133 2021年12月
Human rotavirus strains having the unconventional G4P[6] genotype have been sporadically identified in diarrheic patients in different parts of the world. However, the whole genome of only one human G4P[6] strain from Africa (central Africa) has b...
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