Frontiers in Psychiatry 12 780997-780997 2021年11月 [査読有り]
Our current understanding of melancholic depression is shaped by its position in the depression spectrum. The lack of consensus on how it should be treated—whether as a subtype of depression, or as a distinct disorder altogethe—interferes with the...
<title>Abstract</title>Scintillators emit visible luminescence when irradiated with X-rays. Given the unlimited tissue penetration of X-rays, the employment of scintillators could enable remote optogenetic control of neural functions at any depth ...
Behavioural Brain Research 405 113191-113191 2021年5月 [査読有り]
Tryptophan (TRP) is metabolized via the kynurenine (KYN) pathway, which is related to the pathogenesis of major depressive disorder (MDD). Kynurenine 3-monooxygenase (KMO) is a pivotal enzyme in the metabolism of KYN to 3-hydroxykynurenine. In rod...
Wanpeng Cui   Tomomi Aida   Hikaru Ito   Kenta Kobayashi   Yusaku Wada   Shigeki Kato   Takashi Nakano   Meina Zhu   Kaoru Isa   Kazuto Kobayashi   Tadashi Isa   Kohichi Tanaka   Hidenori Aizawa   
The Journal of Neuroscience 40(38) 7241-7254 2020年8月 [査読有り]
Maladaptation to stress is a critical risk factor in stress-related disorders, such as major depression and post-traumatic stress disorder (PTSD). Dopamine signaling in the nucleus accumbens (NAc) has been shown to modulate behavior by reinforcing...
Frontiers in human neuroscience 14 165-165 2020年 [査読有り]
Human habenula studies are gradually advancing, primarily through the use of functional magnetic resonance imaging (fMRI) analysis of passive (Pavlovian) conditioning tasks as well as probabilistic reinforcement learning tasks. However, no studies...
Takashi Nakano   Catherine Chin   David Mo Aung Myint   Eng Wui Tan   Peter John Hale   John N. J. Reynolds   Jeff Wickens   Keshav M. Dani   
2014 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) 2014年
The development of fast and robust chemical delivery systems is important step for nanomedicine. We demonstrate on-demand, sub-second, controlled release of a neuromodulator by applying femtosecond laser pulse trains to robust, liposome structures.