Resting-state fMRI has the potential to help doctors detect abnormal behavior in brain activity and to diagnose patients with depression. However, resting-state fMRI has a bias depending on the scanner site, which makes it difficult to diagnose de...
Neurochemistry international 122 8-18 2019年1月 [査読有り]
Medium spiny neurons (MSNs) expressing dopamine D1 receptor (D1R) or D2 receptor (D2R) are major components of the striatum. Stimulation of D1R activates protein kinase A (PKA) through Golf to increase neuronal activity, while D2R stimulation inhi...
Stefano Zucca Aya Zucca Takashi Nakano Sho Aoki Jeffery Wickens
eLife 7 2018年3月 [査読有り]
The cholinergic interneurons (CINs) of the striatum are crucial for normal motor and behavioral functions of the basal ganglia. Striatal CINs exhibit tonic firing punctuated by distinct pauses. Pauses occur in response to motivationally significan...
Takashi Nakano Sean M. Mackay Eng Wui Tan Keshav M. Dani Jeff Wickens
eNeuro 3(6) 2016年11月 [査読有り]
External control over rapid and precise release of chemicals in the brain potentially provides a powerful interface with neural activity. Optical manipulation techniques, such as optogenetics and caged compounds, enable remote control of neural ac...
Takashi Nakano Catherine Chin David Mo Aung Myint Eng Wui Tan Peter John Hale John N. J. Reynolds Jeff Wickens Keshav M. Dani
2014 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) 2014年
The development of fast and robust chemical delivery systems is important step for nanomedicine. We demonstrate on-demand, sub-second, controlled release of a neuromodulator by applying femtosecond laser pulse trains to robust, liposome structures.
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