Non-invasive remote control technologies designed to manipulate neural functions have been long-awaited for the comprehensive and quantitative understanding of neuronal network in the brain as well as for the therapy of neurological disorders. Rec...
Takayuki Yamashita   Aurelie Pala   Leticia Pedrido   Yves Kremer   Egbert Welker   Carl C. H. Petersen   
NEURON 80(6) 1477-1490 2013年12月 [査読有り]
Primary sensory cortex discriminates incoming sensory information and generates multiple processing streams toward other cortical areas. However, the underlying cellular mechanisms remain unknown. Here, by making whole-cell recordings in primary s...
NEUROSCIENCE RESEARCH 73(1) 1-7 2012年5月 [査読有り][招待有り]
Action potentials, when arriving at presynaptic terminals, elicit Ca2+ influx through voltage-gated Ca2+ channels. Intracellular [Ca2+] elevation around the channels subsequently triggers synaptic vesicle exocytosis and also induces various protei...
Ca2+ is thought to be essential for the exocytosis and endocytosis of synaptic vesicles. However, the manner in which Ca2+ coordinates these processes remains unclear, particularly at mature synapses. Using membrane capacitance measurements from c...
Hiroyasu Watanabe   Takayuki Yamashita   Naoto Saitoh   Shigeki Kiyonaka   Akihiro Iwamatsu   Kevin P. Campbell   Yasuo Mori   Tomoyuki Takahashi   
JOURNAL OF NEUROSCIENCE 30(2) 655-660 2010年1月 [査読有り]
The synaptic protein interaction (synprint) site of the voltage-gated Ca2+ channel (VGCC)alpha 1 subunit can interact with proteins involved in exocytosis, and it is therefore thought to be essential for exocytosis of synaptic vesicles. Here we re...