Takayuki Yamashita   Takeshi Kanda   Kohgaku Eguchi   Tomoyuki Takahashi   
JOURNAL OF PHYSIOLOGY-LONDON 587(10) 2327-2339 2009年5月 [査読有り]
At central glutamatergic synapses, neurotransmitter often saturates postsynaptic AMPA receptors (AMPARs), thereby restricting the dynamic range of synaptic efficacy. Here, using simultaneous pre- and postsynaptic whole-cell recordings, at the caly...
JOURNAL OF PHYSIOLOGY-LONDON 586(9) 2253-2261 2008年5月 [査読有り]
Ca2+-binding to calmodulin (CaM) causes facilitation and/or inactivation of recombinant Ca2+ channels. At the rat calyx of Held, before hearing onset, presynaptic Ca2+ currents (I-pCa) undergo Ca2+/CaM-dependent inactivation during repetitive acti...
JOURNAL OF PHYSIOLOGY-LONDON 586(9) 2263-2275 2008年5月 [査読有り]
Paired-pulse facilitation (PPF) and depression (PPD) are forms of short-term plasticity that are generally thought to reflect changes in transmitter release probability. However, desensitization of postsynaptic AMPA receptors (AMPARs) significantl...
T Yamashita   T Hige   T Takahashi   
SCIENCE 307(5706) 124-127 2005年1月 [査読有り]
Molecular dependence of vesicular endocytosis was investigated with capacitance measurements at the calyx of Held terminal in brainstem slices. Intraterminal loading of botulinum toxin E revealed that the rapid capacitance transient implicated as ...
T Yamashita   T Ishikawa   T Takahashi   
JOURNAL OF NEUROSCIENCE 23(9) 3633-3638 2003年5月 [査読有り]
Whether a quantal packet of transmitter saturates postsynaptic receptors is a fundamental question in central synaptic transmission. However, this question remains open with regard to saturation at mature synapses. The calyx of Held, a giant gluta...