Takayuki Yamashita Takeshi Kanda Kohgaku Eguchi Tomoyuki Takahashi
JOURNAL OF PHYSIOLOGY-LONDON 587(10) 2327-2339 2009年5月 [査読有り]
At central glutamatergic synapses, neurotransmitter often saturates postsynaptic AMPA receptors (AMPARs), thereby restricting the dynamic range of synaptic efficacy. Here, using simultaneous pre- and postsynaptic whole-cell recordings, at the caly...
JOURNAL OF PHYSIOLOGY-LONDON 586(9) 2253-2261 2008年5月 [査読有り]
Ca2+-binding to calmodulin (CaM) causes facilitation and/or inactivation of recombinant Ca2+ channels. At the rat calyx of Held, before hearing onset, presynaptic Ca2+ currents (I-pCa) undergo Ca2+/CaM-dependent inactivation during repetitive acti...
Maki Koike-Tani Takeshi Kanda Naoto Saitoh Takayuki Yamashita Tomoyuki Takahashi
JOURNAL OF PHYSIOLOGY-LONDON 586(9) 2263-2275 2008年5月 [査読有り]
Paired-pulse facilitation (PPF) and depression (PPD) are forms of short-term plasticity that are generally thought to reflect changes in transmitter release probability. However, desensitization of postsynaptic AMPA receptors (AMPARs) significantl...
Molecular dependence of vesicular endocytosis was investigated with capacitance measurements at the calyx of Held terminal in brainstem slices. Intraterminal loading of botulinum toxin E revealed that the rapid capacitance transient implicated as ...
JOURNAL OF NEUROSCIENCE 23(9) 3633-3638 2003年5月 [査読有り]
Whether a quantal packet of transmitter saturates postsynaptic receptors is a fundamental question in central synaptic transmission. However, this question remains open with regard to saturation at mature synapses. The calyx of Held, a giant gluta...
お知らせ・マニュアル
医学部