Brandon C. Rosen   Nicholas A. Dillon   Nicholas D. Peterson   Yusuke Minato   Anthony D. Baughn   
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 61(2) 2017年2月 [査読有り]
Pyrazinamide (PZA) is a first-line tuberculosis (TB) drug that has been in clinical use for 60 years yet still has an unresolved mechanism of action. Based upon the observation that the minimum concentration of PZA required to inhibit the growth o...
Kucers the Use of Antibiotics 2488-2492 2017年1月 [査読有り]
<p>para-Aminosalicylic acid (PAS) is one of the oldest antitubercular drugs, and first entered clinical use in 1944 (Lehmann, 1946). PAS (chemical structure shown in Figure 131.1), a structural analog of the folate precursor paraaminobenzoic acid ...
Joshua M. Thiede   Shannon L. Kordus   Breanna J. Turman   Joseph A. Buonomo   Courtney C. Aldrich   Yusuke Minato   Anthony D. Baughn   
SCIENTIFIC REPORTS 6 2016年12月 [査読有り]
The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underutilized drug class in tuberculosis (TB) therapy...
JOURNAL OF BACTERIOLOGY 198(17) 2307-2317 2016年9月 [査読有り]
We searched for a source of reactive oxygen species (ROS) in the cytoplasm of the human pathogen Vibrio cholerae and addressed the mechanism of ROS formation using the dye 2',7'-dichlorofluorescein diacetate (DCFH-DA) in respiring cells. By compar...