Yusuke Minato   Joshua M. Thiede   Shannon Lynn Kordus   Edward J. McKlveen   Breanna J. Turman   Anthony D. Baughn   
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 59(9) 5097-5106 2015年9月 [査読有り]
para-Aminosalicylic acid (PAS) entered clinical use in 1946 as the second exclusive drug for the treatment of tuberculosis (TB). While PAS was initially a first-line TB drug, the introduction of more potent antitubercular agents relegated PAS to t...
We previously described the cloning of genes related to drug resistance from Klebsiella pneumoniae MGH78578. Of these, we identified a putative gene encoding a MATE-type multidrug efflux pump, and named it ketM. Escherichia coli KAM32 possessing k...
Yusuke Minato   Sara R. Fassio   Jay S. Kirkwood   Petra Halang   Matthew J. Quinn   Wyatt J. Faulkner   Alisha M. Aagesen   Julia Steuber   Jan F. Stevens   Claudia C. Haese   
PLOS ONE 9(5) 2014年5月 [査読有り]
The Na+ translocating NADH: quinone oxidoreductase (Na+-NQR) is a unique respiratory enzyme catalyzing the electron transfer from NADH to quinone coupled with the translocation of sodium ions across the membrane. Typically, Vibrio spp., including ...
Yusuke Minato   Sara R. Fassio   Rylan L. Reddekopp   Claudia C. Haese   
MICROBIAL PATHOGENESIS 66 36-39 2014年1月 [査読有り]
Two virulence factors produced by Vibrio cholerae, cholera toxin (CT) and toxin-corregulated pilus (TCP), are indispensable for cholera infection. ToxT is the central' regulatory protein involved in activation of CT and TCP expression. We previous...
Yusuke Minato   Amit Ghosh   Wyatt J. Faulkner   Erin J. Lind   Sara Schesser Bartra   Gregory V. Plano   Clayton O. Jarrett   B. Joseph Hinnebusch   Judith Winogrodzki   Pavel Dibrov   Claudia C. Haese   
INFECTION AND IMMUNITY 81(9) 3163-3172 2013年9月 [査読有り]
Na+/H+ antiporters are ubiquitous membrane proteins that play a central role in the ion homeostasis of cells. In this study, we examined the possible role of Na+/H+ antiport in Yersinia pestis virulence and found that Y. pestis strains lacking the...