UNLABELLED: Streptococcus pyogenes causes a variety of human infections, and hospital outbreaks with this pathogen have also been reported. The purpose of this study is to describe the clinical characteristics of an outbreak of S. pyogenes involvi...
Alina Iovleva Christi L McElheny Erin L Fowler Eric Cober Erica S Herc Cesar A Arias Carol Hill Keri Baum Vance G Fowler Jr Henry F Chambers Kerryl E Greenwood-Quaintance Robin Patel David van Duin Robert A Bonomo Yohei Doi
Antimicrobial agents and chemotherapy 68(3) e0125823 2024年3月
The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U...
With the coronavirus disease 2019 (COVID-19) pandemic, there is growing interest in utilizing adaptive platform clinical trials (APTs), in which multiple drugs are compared with a single common control group, such as a placebo or standard-of-care ...
Anna Clara M Galdino Mylene Vaillancourt Diana Celedonio Kara Huse Yohei Doi Janet S Lee Peter Jorth
Nature microbiology 9(3) 631-646 2024年3月
The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-lactamase degradation. While effective, resistance has been detected clinically with unknown mechanisms. Here, using experimental evolution, we identified ...
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