業績

代表論文リスト

Hada K, Wulaer B, Nagai T*, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Mol. Brain, 14, 21, 2021. (*co-first author)

Lin Y-H, Yamahashi Y, Kuroda K, Faruk MO, Zhang X, Yamada K, Yamanaka A, Nagai T#, Kaibuchi K. Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurocham. Int. 143, 104935, 2021. (#corresponding author).
 
Wulaer B, Nagai T*#, Sobue A, Itoh N, Kuroda K, Kaibuchi K, Nabeshima T, Yamada K. Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1Δ2-3/Δ2-3 mice. Gene Brain Behav. e12478, 2018. (*co-first author, #corresponding author). 
 
Shan W, Nagai T*#, Tanaka M, Itoh N, Furukawa-Hibi Y, Nabeshima T, Sokabe M, Yamada K. Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. J. Neurochem. 145, 19-33, 2018. (*co-first author, #corresponding author). 
 
Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K. Phosphoproteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. Neuron 89, 550–565, 2016. 
 
Nakai T, Nagai T*, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah AB, Sokabe M, Takahashi M, Yamada K. Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. J. Neurosci. 34, 14995-15008, 2014. (*co-first author). 
 
Ibi D, Nagai T*, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano SI, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K. Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia 61, 679-693, 2013. (*co-first author).
 
Yun J, Nagai T*, Furukawa-Hibi Y, Kuroda K, Kaibuchi K, Greenberg ME, Yamada K. Neuronal PAS domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I. J. Biol. Chem. 288, 2655-2664, 2013. (*co-first author). 
 
Takahashi, K., Nagai, T.*, Kamei, H., Maeda, K., Matsuya, T., Arai, S., Mizoguchi, H., Yoneda, Y., Nabeshima, T., Takuma, K. and Yamada, K. Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice. Biol. Psychiatry 62, 148-157, 2007. (*co-first author). 
 
Nagai T, Ito M, Nakamichi N, Mizoguchi H, Kamei H, Fukakusa A, Nabeshima T, Takuma K, Yamada K. The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1. J. Neurosci. 26, 12374-12383, 2006. 
 
Nagai T, Yamada K, Yoshimura M, Ishikawa K, Miyamoto Y, Hashimoto K, Noda Y, Nitta A, Nabeshima T. Tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release. Proc. Natl. Acad. Sci. USA 101, 3650-3655, 2004.

2022

Faruk MO, Tsuboi D, Yamahashi Y, Funahashi Y, Lin YH, Ahammad RU, Hossen E, Amano M, Nishioka T, Tzingounis AV, Yamada K, Nagai T, Kaibuchi K. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. J. Neurochem., 160, 325-341, 2022.  

Liao J, Dong G, Wulaer B, Sawahata M, Mizoguchi H, Mori D, Ozaki N, Nabeshima T, Nagai T, Yamada K. Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks. Behav. Brain Res., 416, 113569, 2022.

Takase S, Liao J, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada, K. Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. Eur. J. Pharmacol., 931, 175207,2022.

Ito A, Ichikawa K, Miyazaki M, Sagara A, Motegi T, Ando Y, Senzaki K, Nagai T, Yamada K. Clinical impact of standardized creatinine on dose adjustment of capecitabine. Nagoya J Med Sci., 84, 547-553, 2022.

Yamahashi Y, Lin YH, Mouri A, Iwanaga S, Kawashima K, Tokumoto Y, Watanabe Y, Faruk MO, Zhang X, Tsuboi D, Nakano T, Saito N, Nagai T, Yamada K, Kaibuchi K. Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning. Mol. Psychiatry in press.

Tsuboi D, Otsuka T, Shimomura T, Faruk MO, Yamahashi Y, Amano M, Funahashi Y, Kuroda K, Nishioka T, Kobayashi K, Sano H, Nagai T, Yamada K, Tzingounis AV, Nambu A, Kubo Y, Kawaguchi Y, Kaibuchi K. Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior. Cell Rep., 40, 111309, 2022.

Kubota H, Kunisawa K, Niijima M, Hirakawa M, Mori Y, Hasegawa M, Fujigaki S, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine. Biochem. Biophys. Res. Commun., 629, 142-151, 2022. 

Zhang X, Tsuboi D, Funahashi Y, Yamahashi Y, Kaibuchi K, Nagai T. Phosphorylation signals downstream of dopamine receptors in emotional behaviors: Association with preference and avoidance. (Review) Int. J. Mol. Sci., 23, 11643, 2022.

Kuroiwa M, Shuto T, Nagai T, Amano M, Kaibuchi K, Nairn AC, Nishi A. DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum. Neurochem. Int., in press.

Tanaka R, Liao J, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene. Pharmacol Res.,187, 106589, 2022 

Zhang X, Kitaichi K, Mouri A, Zhou X, Nabeshima T, Yamada K, Nagai T. An evaluation method for developing abuse-deterrent opioid formulations with agonist and antagonist combinations using conditioned place preference. Biochem. Biophys. Res. Commun., 639, 100-105, 2022. 

2021

Ahammad RU, Nishioka T, Yoshimoto J, Kannon T, Amano M, Funahashi Y, Tsuboi D, Faruk MO, Yamahashi Y, Yamada K, Nagai T, Kaibuchi K. KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain. Cells 11, 47, 2021.

Sawahata M, Asano H, Nagai T, Ito N, Kohno T, Nabeshima T, Hattori M, Yamada K. Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice. Pharmacol. Res. 173, 105832, 2021.
 
Lin Y-H, Yamahashi Y, Kuroda K, Faruk MO, Zhang X, Yamada K, Yamanaka A, Nagai T#, Kaibuchi K. Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurocham. Int. 143, 104935, 2021. (#corresponding author).
 
Hada K, Wulaer B, Nagai T*, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Mol. Brain 14, 21, 2021. (*co-first author)
 
Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Nagai T, Yamada K, Arima H. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice. Sci. Rep. 11, 12873, 2021.
 
Ariza A, Funahashi Y, Kozawa S, Omar Faruk M, Nagai T, Amano M, Kaibuchi K. Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK. J. Neurochem. 157, 1774-1788, 2021.
 
Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K. Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia. Neurochem. Int. 144, 104954, 2021.
 
Wulaer B, Kunisawa K, Hada K, Jaya Suento W, Kubota H, Iida T, Kosuge A, Nagai T, Yamada K, Nitta A, Yamamoto Y, Saito K, Mouri A, Nabeshima T. Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus. J. Neurochem. 157, 642-655, 2021.

2020

Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus. Transl. Psychiatry 10, 35, 2020.
 
Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, Sobue A, Shishido E, Sekiguchi M, Kodama A, Ikeda R, Aleksic B, Kimura H, Ishizuka K, Nagai T, Kaibuchi K, Nabeshima T, Yamada K, Ozaki N. Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia. Psychiatry Clin. Neurosci. 74, 318-327, 2020.
 
Hori K, Yamashiro K, Nagai T, Shan W, Egusa SF, Shimaoka K, Kuniishi H, Sekiguchi M, Go Y, Tatsumoto S, Yamada M, Shiraishi R, Kanno K, Miyashita S, Sakamoto A, Abe M, Sakimura K, Sone M, Sohya K, Kunugi H, Wada K, Yamada M, Yamada K, Hoshino M. AUTS2 regulation of synapses for proper synaptic inputs and social communication. iScience 23, 101183, 2020.
 
Sekiguchi M, Sobue A, Kushima I, Wang C, Arioka Y, Kato H, Kodama A, Kubo H, Ito N, Sawahata M, Hada K, Ikeda R, Shinno M, Mizukoshi C, Tsujimura K, Yoshimi A, Ishizuka K, Takasaki Y, Kimura H, Xing J, Yu Y, Yamamoto M, Okada T, Shishido E, Inada T, Nakatochi M, Takano T, Kuroda K, Amano M, Aleksic B, Yamomoto T, Sakuma T, Aida T, Tanaka K, Hashimoto R, Arai M, Ikeda M, Iwata N, Shimamura T, Nagai T, Nabeshima T, Kaibuchi K, Yamada K, Mori D, Ozaki N. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Transl. Psychiatry 10, 247, 2020.  
 
Ibi D, Nakasai G, Koide N, Sawahata M, Kohno T, Takaba R, Nagai T, Hattori M, Nabeshima T, Yamada K, Hiramatsu M. Reelin supplementation into the hippocampus rescues abnormal behavior in a mouse model of neurodevelopmental disorders. Front. Cell. Neurosci. 14, 285, 2020.