‹Æ@Ñ
@@2006
@`2005
@TOP@PAGE

@

@

‰¢•¶ŽGŽ

Shizuko Nagao, Kazuhiro Nishii, Makoto Katsuyama, Hiroki Kurahashi, Tohru Marunouchi, Hisahide Takahashi H, Darren P Wallace. Increased water intake decreases progression of polycystic kidney disease in the PCK rat. J Am Soc Nephrol. 17(8):2220-2227. 2006
Comment in:J Am Soc Nephrol. 2006 Aug;17(8):2089-2091.

˜a•¶–{

’·”öÃŽqA¼ˆäˆêGAûü‹´‹v‰p@“®•¨‚ÌPKDˆâ“`Žq•ÏˆÙ@pp.40-47.@
“ŒŒ´‰p“ñ@iŠÄCj@‘½”­«”X–Et‚Ì‘S‚Ä@
ƒCƒ“ƒ^[ƒƒfƒBƒJA“Œ‹žA2006

’·”öÃŽqA¼ˆäˆêGAûü‹´‹v‰p@¶Šˆã‚Ì’ˆÓ@pp.326-329.@
“ŒŒ´‰p“ñiŠÄCj@‘½”­«”X–Et‚Ì‘S‚Ä@ƒCƒ“ƒ^[ƒƒfƒBƒJA“Œ‹žA2006



‘ÛŠw‰ïE“Á•Êu‰‰“™

Kazuhiro Nishii, Shizuko Nagao, Makoto Katsuyama, Hiroki Kurahashi, Tohru Marunouchi, Hisahide Takahashi, Darren P Wallace. Effect of increased water intake in rodent ARPKD. 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, Japan, 2006

Daisuke Yoshihara, Kazuhiro Nishii, Tsunoda, H., Inoue, T., Nakamura, S., Fujiki, H., Mori, T., Kayuri Nagaoka, Hiroki Kurahashi, Hisahide Takahashi, Darren P Wallace, Shizuko Nagao. Dose Response Effect of Tolvaptan (OPC-41061), Administered Twice-daily by Gavage, on Urine Osmolality in SD and PCK rats. American Society of Nephrology 39th Annual Meeting & Scientific Exposition, San Diego, CA, USA, 2006



‘“àŠw‰ïE“Á•Êu‰‰“™

’·”öÃŽqA‹gŒ´‘å•ãA¼ˆäˆêGAûü‹´‹v‰p@t×–E“à‚̃Jƒ‹ƒVƒ…ƒEƒ€”Z“x‚̓‚ƒfƒ‹“®•¨‚Å‚ ‚éCy/+‚Ì”X–EtÇ‚Ìis‚ɉe‹¿‚ð—^‚¦‚é‚©H@‘æ53‰ñ“ú–{ŽÀŒ±“®•¨Šw‰ï‘‰ï@_ŒËi2006j

’·”öÃŽqA¼ˆäˆêGAŸŽR@TAûü‹´‹v‰pAWallace, DP. Dose High Water Intake Reduce Progression of Rodent Polycystic Kidney Disease? ‘æ49‰ñ“ú–{t‘ŸŠw‰ïŠwp‘‰ï@“Œ‹ži2006j

’·”öÃŽqA‹gŒ´‘å•ãA¼ˆäˆêGAûü‹´‹v‰p@Ž¾Š³ƒ‚ƒfƒ‹“®•¨‚ð—p‚¢‚½Šî‘bŒ¤‹†‚ªˆã—ÂÉvŒ£‚·‚é–ðŠ„-‘½”­«”X–EtiPKDj-@‘æ‚P‰ñ“ú–{—Õ°ŒŸ¸Šw‹³ˆçŠw‰ïŠwp‘å‰ï@“Œ‹ži2006j

¼ˆäˆêGA‹gŒ´‘å•ãA“¡–{LŒáA“ú‚’qŽqA’·”öÃŽqAûü‹´‹v‰p@t×–E“àƒJƒ‹ƒVƒEƒ€”Z“x‚ª‘½”­«”X–Etǃ‚ƒfƒ‹‚ÌÇóis‚Æt‹@”\‚Ö‹y‚Ú‚·‰e‹¿@‘æ‚P‰ñ“ú–{—Õ°ŒŸ¸Šw‹³ˆçŠw‰ïŠwp‘å‰ï@“Œ‹ži2006j

“¡–{LŒáA“ú‚’qŽqA‹gŒ´‘å•ãA¼ˆäˆêGA’·”öÃŽqAûü‹´‹v‰p@‘½”­«”X–Etǃ‚ƒfƒ‹ƒ‰ƒbƒg‚É‚¨‚¯‚é[•ª‚È…•ªÛŽæ‚ªt‹@”\‚É‚à‚½‚ç‚·Œø‰Ê@‘æ‚P‰ñ“ú–{—Õ°ŒŸ¸Šw‹³ˆçŠw‰ïŠwp‘å‰ï@“Œ‹ži2006j

¼ˆäˆêGA‹gŒ´‘å•ãA’·‰ª•S‡AŸŽR@TA‘q‹´_Ž÷AŠÛ–ì“àž¦Aûü‹´‹v‰pAWallace, DPA’·”öÃŽq@”X–E«t‘ŸŽ¾Š³ƒ‚ƒfƒ‹‚É‚¨‚¯‚é…•ªÛŽæ‚ª‚à‚½‚ç‚·‰e‹¿@“ú–{•ªŽq¶•¨Šw‰ï2006ƒtƒH[ƒ‰ƒ€@–¼ŒÃ‰®i2006j

‰Hª“cç]”üAûü‹´‹v‰p@“î‚wü”­¶‘•’u‚r‚n‚e‚q‚n‚m‚Ì—LŒøŠˆ—p@•ñ‚P@|”X–EtÇ‚Ö‚ÌŠˆ—p|@‘æ40‰ñ“ú–{ŽÀŒ±“®•¨‹ZpŽÒ‹¦‰ï‘‰ï@‹ž“si2006j


’n•ûŠw‰ï

¼ˆäˆêGA‹gŒ´‘å•ãA“¡–{LŒáA“ú‚’qŽqA’·‰ª•S‡A‘q‹´_Ž÷AŠÛ–ì“àž¦A’·”öÃŽqAûü‹´‹v‰p@‘½”­«”X–Etǂ̃‚ƒfƒ‹“®•¨‚Å‚ ‚éHan:SPRD(Cy) ƒ‰ƒbƒg‚ð—p‚¢‚½”X–EŒ`¬‹@˜‚̉ð–¾@‘æ38‰ñ“¡“cŠw‰€ˆãŠw‰ï‘‰ï@–L–¾i2006j

–ö¶@–ÎA‘å–ì’mŽuA“¡“c‚½‚¦ŽqA‹àŽqç”VA¬•Û•üŽqA–q–ì—F”üA猴@–ÒA•Ê•{G•FAûü‹´‹v‰p@H‰–‚Š´Žó«ƒ‰ƒbƒg(Dahl/S)‹y‚ÑH‰–’ኴŽó«ƒ‰ƒbƒg(Dahl/R)‚ÌŽ“—Y‚É‚¨‚¯‚錌ˆ³•Ï“®@‘æ38‰ñ“¡“cŠw‰€ˆãŠw‰ï@–L–¾i2006j

‰Hª“cç]”üA“¡“c‚½‚¦ŽqAŠÖŒû@ŒbA‚‹´”ü•äAŒã“¡’mAûü‹´‹v‰p@‹}«ƒAƒ‹ƒR[ƒ‹ŠÌáŠQƒ}ƒEƒX‚É‚¨‚¯‚éƒVƒWƒ~ƒGƒLƒX“Š—^‚̉e‹¿@‘æ38‰ñ“¡“cŠw‰€ˆãŠw‰ï@–L–¾i2006j

’·‰ª•S‡A¼ˆäˆêGA‹gŒ´‘å•ãA“¡–{LŒáA“ú‚’qŽqA‘q‹´_Ž÷AŠÛ–ì“àž¦A’·”öÃŽqAûü‹´‹v‰pA‘½”­«”X–E«tŽ¾Š³‚ÌÓ”Cˆâ“`Žq‚Å‚ ‚éNphp3 ‚̉ðÍ@‘æ38‰ñ“¡“cŠw‰€ˆãŠw‰ï@–L–¾i2006j

’·‰ªrŽ¡A‘¾“cŒ´T–çAŽs쉀‰ÀAûü‹´‹v‰p@‰^“®áŠQƒ}ƒEƒXB6-wob‚Ìs“®‚ƶ—@‘æ38‰ñ“¡“cŠw‰€ˆãŠw‰ï‘‰ï@–L–¾i2006j

‘O“c@‹IA“¡“c‚½‚¦ŽqA’؈ä@½AŽ›˜e@FAûü‹´‹v‰p@ƒCƒ“ƒhA•¨ƒj[ƒ€—t’Šo•¨‚ð“Y‰Á‚µ‚½ˆù—¿…‚É‚æ‚é‚Rƒ–ŒŽŠÔ‚̘A‘±“Š—^ŽŽŒ±‰Á[ƒ}ƒEƒX]@‘æ38‰ñ“¡“cŠw‰€ˆãŠw‰ï‘‰ï@–L–¾i2006j


Œ¤‹†‰ï“™

’·”öÃŽq@u‘½”­«”X–Et‚ÌÅVî•ñv…‚ðÏ‹É“I‚Ɉù‚Þ‚ÆPKD‚Ìis‚ð—}§‚Å‚«‚éH@‘½”­«”X–Età’c“ú–{Žx•”u‰‰‰ï@“Œ‹ži2006j

¼ˆäˆêGA‹gŒ´‘å•ãAûü‹´‹v‰pAWallace, DPAŽR‰ºÏ“¿A’·”öÃŽq@t×–E“àƒJƒ‹ƒVƒEƒ€”Z“x‚ªPKD‚Ìt‹@”\‚É‹y‚Ú‚·‰e‹¿iƒ‚ƒfƒ‹“®•¨‚É‚¨‚¯‚錟“¢j@‘æ14‰ñ”X–E«tŽ¾Š³Œ¤‹†‰ï@“Œ‹ži2006j

’·”öÃŽqA¼ˆäˆêGA‘q‹´_Ž÷AŠÛ–ì“àž¦Aûü‹´‹v‰p@”X–E«tŽ¾Š³‚Ìis‚ð—}§‚·‚éˆöŽq@•½¬17”N“x‘‡ˆã‰ÈŠwŒ¤‹†ŠŒ¤‹†•ñ‰ï@–L–¾i2006j

’·‰ª•S‡A¼ˆäˆêGA’·”öÃŽqAŒüŒã@Š°A‰Í˜aŠ°ŒbAŽR“cWŽiAûü‹´‹v‰pA‘q‹´_Ž÷@”X–E«tŽ¾Š³ƒ‚ƒfƒ‹(pcyƒ}ƒEƒX)‚É‚¨‚¯‚éÓ”Cˆâ“`ŽqNphp3 ‚̉ðÍ@•½¬17”N“x‘‡ˆã‰ÈŠwŒ¤‹†ŠŒ¤‹†•ñ‰ï@–L–¾i2006j

’·”öÃŽqA¼ˆäˆêGA–ö¶–ÎAûü‹´‹v‰p@t‘Ÿ‚É‚¨‚¯‚é×–E“àî•ñ“`’BŒn‚̉ðÍ‚ÆV‹KŽ¡—Ö@‚ÌŠJ”­@“¡“c•ÛŒ’‰q¶‘åŠwƒnƒCƒeƒNEƒŠƒT[ƒ`EƒZƒ“ƒ^[Œ¤‹†¬‰Ê•ñ‰ï@–L–¾@(2006)

’·”öÃŽqA¼ˆäˆêGA–ö¶–ÎAûü‹´‹v‰p@ƒnƒCƒeƒNƒtƒƒ“ƒeƒBƒA‚Å®”õ‚³‚ꂽ‚r‚o‚eŽ”ˆçŽº‚̉^—pó‹µ@“¡“c•ÛŒ’‰q¶‘åŠwƒnƒCƒeƒNEƒŠƒT[ƒ`EƒZƒ“ƒ^[Œ¤‹†¬‰Ê•ñ‰ï@–L–¾@(2006)


@

@Ž¾Š³ƒ‚ƒfƒ‹‹³ˆçŒ¤‹†ƒZƒ“ƒ^[‚Í2005”N‚ÉŠJÝ30Žü”N‚ðŒ}‚¦A‚±‚ê‚ð‹L”O‚µ‚Ä‹I—vW‚ðo”Å‚µA2001`2005”N‚Ì‹ÆÑ‚ð‚Ü‚Æ‚ß‚Ü‚µ‚½B

@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@
ƒZƒ“ƒ^[‹³EˆõŠÖ˜A‚Ì‹ÆÑ‚Í‚±‚¿‚ç@


ŒfÚ‚Ì•¶ÍEŽÊ^E}•\‚È‚Ç‚Ì–³’f“]Ú‚ð‹ÖŽ~‚µ‚Ü‚·B’˜ìŒ ‚ÍŽ¾Š³ƒ‚ƒfƒ‹‹³ˆçŒ¤‹†ƒZƒ“ƒ^[‚É‘®‚µ‚Ü‚·B