総合医科学研究所 システム医科学
発表論文 20件
1. Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, *Yamakawa K. Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity. Molecular Autism. doi: 10.1186/s13229-019-0265-5. (2019 Mar)
2. Shoji H, *Miyakawa T. Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program. Neuropsychopharmacol Reports. [Epub ahead of print]. doi: 10.1002/npr2.12052. (2019 Feb)
3. Hagihara H, Ohira K, *Miyakawa T. Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex. Neuropsychopharmacol Reports. [Epub ahead of print]. doi: 10.1002/npr2.12048. (2019 Feb)
4. Koshimizu H, Nogawa S, Asano S, Ikeda M, Iwata N, Takahashi S, *Saito K, *Miyakawa T. Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population. Translational Psychiatry. 9(1):52. doi: 10.1038/s41398-019-0383-z. (2019 Jan)
5. Murano T, Hagihara H, Tajinda K, Matsumoto M, *Miyakawa T. Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders. Communications Biology. 2; 32. doi.org/10.1038/s42003-018-0277-2. (2019 Jan)
6. Hattori S, Okumura Y, Takao K, Yamaguchi Y, *Miyakawa T. Open source code for behavior analysis in rodents.s. Neuropsychopharmacology Reports. [Epub ahead of print] doi: 10.1002/npr2.12047. (2019 Jan)
7. *Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Mito T, Matsumoto H, Miyakawa T, Nakada K. Acquired expression of mutant Mitofusin 2 causes progressive neurodegeneration and abnormal behavior. Journal of Neuroscience. pii: 2139-18 [Epub ahead of print] doi: 10.1523/JNEUROSCI.2139-18.2018. (2019 Jan)
8. Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Oh YS, Jang JH, Shin CH, Ohnishi YN, Hanada Y, Miyakawa T, Kim Y, Greengard P, *Nishi A. Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine. Molecular Psychiatry. [Epub ahead of print] doi: 10.1038/s41380-018-0316-x. (2018 Dec)
9. Koshimizu H, Hirata N, Takao K, Toyama K, Ichinose T, Furuya S, *Miyakawa T. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology Reports. [Epub ahead of print] doi: 10.1002/npr2.12041. (2018 Nov)
10. *Katano T, Takao K, Abe M, Yamazaki M, Watanabe M, Miyakawa T, Sakimura K, Ito S. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Molecular Brain.11(1):63. doi.org/10.1186/s13041-018-0407-2. (2018 Oct)
11. Global Neuroethics Summit Delegates, Rommelfanger KS, Jeong SJ, Ema A, Fukushi T, Kasai K, Ramos KM, Salles A, Singh I. Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives. Neuron. 100(1):19-36. doi: 10.1016/j.neuron.2018.09.021. (2018 Oct)
12. Kobayashi K, Takagi T, Ishii S, Suzuki H, Miyakawa T. Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. Molecular Brain. 11(1):56. doi: 10.1186/s13041-018-0400-9. (2018 Oct)
13. Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, *Shirakawa H, Kaneko S. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Research. pii: S0006-8993(18)30496-7. 1704:68-77. doi: 10.1016/j.brainres.2018.09.031. (2019 Jan) (Epub ahead 2018 Sep)
14. Hirata N, Hattori S, Shoji H, Funakoshi H, *Miyakawa T. Comprehensive behavioral analysis of indoleamine 2,3-dioxygenase knockout mice. Neuropsychopharmacology Reports. 38(3):133-144. doi: 10.1002/npr2.12019. (2018 Sep)
15. Kanetake T, *Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, *Kihara A. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. FASEB JOURNAL. 7:fj201800291R. doi: 10.1096/fj.201800291R. (2018 Aug)
16. Shoji H, *Miyakawa T. Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study. Molecular Brain. 11(1):42. doi: 10.1186/s13041-018-0382-7. (2018 Jul)
17. Hagihara H, Fujita M, Umemori J, Hashimoto M, *Miyakawa T. Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein. Molecular Brain. 11(1):38. doi: 10.1186/s13041-018-0378-3 (2018 Jul)
18. Inoue R, Talukdar G, Takao K, Miyakawa T, *Mori H. Dissociated Role of D-Serine in Extinction During Consolidation vs. Reconsolidation of Context Conditioned Fear. Frontiers in Molecular Neuroscience. 11:161. doi: 10.3389/fnmol.2018.00161 (2018 May)
19. Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy SE, Miyakawa T, *Kataoka T. Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain. Molecular Brain. 11(1):27. doi: 10.1186/s13041-018-0370-y. (2018 May)
20. Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, *Tanaka T. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. PLoS One. 13(4):e0196587. doi: 10.1371/journal.pone.0196587. (2018 Apr)
2. Shoji H, *Miyakawa T. Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program. Neuropsychopharmacol Reports. [Epub ahead of print]. doi: 10.1002/npr2.12052. (2019 Feb)
3. Hagihara H, Ohira K, *Miyakawa T. Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex. Neuropsychopharmacol Reports. [Epub ahead of print]. doi: 10.1002/npr2.12048. (2019 Feb)
4. Koshimizu H, Nogawa S, Asano S, Ikeda M, Iwata N, Takahashi S, *Saito K, *Miyakawa T. Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population. Translational Psychiatry. 9(1):52. doi: 10.1038/s41398-019-0383-z. (2019 Jan)
5. Murano T, Hagihara H, Tajinda K, Matsumoto M, *Miyakawa T. Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders. Communications Biology. 2; 32. doi.org/10.1038/s42003-018-0277-2. (2019 Jan)
6. Hattori S, Okumura Y, Takao K, Yamaguchi Y, *Miyakawa T. Open source code for behavior analysis in rodents.s. Neuropsychopharmacology Reports. [Epub ahead of print] doi: 10.1002/npr2.12047. (2019 Jan)
7. *Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Mito T, Matsumoto H, Miyakawa T, Nakada K. Acquired expression of mutant Mitofusin 2 causes progressive neurodegeneration and abnormal behavior. Journal of Neuroscience. pii: 2139-18 [Epub ahead of print] doi: 10.1523/JNEUROSCI.2139-18.2018. (2019 Jan)
8. Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Oh YS, Jang JH, Shin CH, Ohnishi YN, Hanada Y, Miyakawa T, Kim Y, Greengard P, *Nishi A. Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine. Molecular Psychiatry. [Epub ahead of print] doi: 10.1038/s41380-018-0316-x. (2018 Dec)
9. Koshimizu H, Hirata N, Takao K, Toyama K, Ichinose T, Furuya S, *Miyakawa T. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology Reports. [Epub ahead of print] doi: 10.1002/npr2.12041. (2018 Nov)
10. *Katano T, Takao K, Abe M, Yamazaki M, Watanabe M, Miyakawa T, Sakimura K, Ito S. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Molecular Brain.11(1):63. doi.org/10.1186/s13041-018-0407-2. (2018 Oct)
11. Global Neuroethics Summit Delegates, Rommelfanger KS, Jeong SJ, Ema A, Fukushi T, Kasai K, Ramos KM, Salles A, Singh I. Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives. Neuron. 100(1):19-36. doi: 10.1016/j.neuron.2018.09.021. (2018 Oct)
12. Kobayashi K, Takagi T, Ishii S, Suzuki H, Miyakawa T. Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. Molecular Brain. 11(1):56. doi: 10.1186/s13041-018-0400-9. (2018 Oct)
13. Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, *Shirakawa H, Kaneko S. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Research. pii: S0006-8993(18)30496-7. 1704:68-77. doi: 10.1016/j.brainres.2018.09.031. (2019 Jan) (Epub ahead 2018 Sep)
14. Hirata N, Hattori S, Shoji H, Funakoshi H, *Miyakawa T. Comprehensive behavioral analysis of indoleamine 2,3-dioxygenase knockout mice. Neuropsychopharmacology Reports. 38(3):133-144. doi: 10.1002/npr2.12019. (2018 Sep)
15. Kanetake T, *Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, *Kihara A. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. FASEB JOURNAL. 7:fj201800291R. doi: 10.1096/fj.201800291R. (2018 Aug)
16. Shoji H, *Miyakawa T. Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study. Molecular Brain. 11(1):42. doi: 10.1186/s13041-018-0382-7. (2018 Jul)
17. Hagihara H, Fujita M, Umemori J, Hashimoto M, *Miyakawa T. Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein. Molecular Brain. 11(1):38. doi: 10.1186/s13041-018-0378-3 (2018 Jul)
18. Inoue R, Talukdar G, Takao K, Miyakawa T, *Mori H. Dissociated Role of D-Serine in Extinction During Consolidation vs. Reconsolidation of Context Conditioned Fear. Frontiers in Molecular Neuroscience. 11:161. doi: 10.3389/fnmol.2018.00161 (2018 May)
19. Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy SE, Miyakawa T, *Kataoka T. Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain. Molecular Brain. 11(1):27. doi: 10.1186/s13041-018-0370-y. (2018 May)
20. Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, *Tanaka T. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. PLoS One. 13(4):e0196587. doi: 10.1371/journal.pone.0196587. (2018 Apr)
学会発表（国際）6件
1. 2018年12月21-22日
AINI 2018 (Advances in Neuroinformatics) (6th INCF Japan Node International Workshop) (和光市広沢)
Tsuyoshi Miyakawa, Akira Sato
Organized Session “Large Scale Mouse Brain Data”
Tsuyoshi Miyakawa
“Endophenotype in the brain: A key concept for understanding the relationships between genes and behavior”
2. 2018年11月1-2日
Molecular and Cellular Cognition Society (MCCS) 17th Annual Symposium (San Diego, CA)
Tomoyuki Murano, Tsuyoshi Miyakawa
“Spatial and Speed Information are differentially encoded in the Population Activity of Dentate Gyrus Neurons”
3. 2018年10月2-5日
The 13th International Conference of Neurons and Brain Diseases, AND meeting (Taipei, Taiwan)
Tsuyoshi Miyakawa
“Short-and long-term dematuration and its molecular mechanisms.”
Hirotaka Shoji, Keizo Takao, Satoko Hattori, Tsuyoshi Miyakawa（2018.10.3）
“Age-related behavioral changes from young adulthood to middle age in C57BL/6J mice”
4. 2018年9月25-28日
Cold Spring Harbor Asia meeting on Latest Advances in Development & Function of Neuronal Circuits (CSHL) （淡路夢舞台カンファレンスセンター、兵庫県）
Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo (2018.9.26)
“DNA polymerase β is required for postnatal hippocampal development and function.”
Tomoyuki Murano
“Spatial and Speed Information are differentially coded in Population Activity of Dentate Gyrus Neurons”
5. 2018年8月26-28日
2nd Pain and Emotion Summer Meeting, Association for the Study of Neurons and Diseases (ASND) (Toronto, Canada)
Tsuyoshi Miyakawa (2018.8.26)
“Decreased pH and increased lactate in the brains of animal models of depression.”
6. 2018年6月16-19日
CINP (The Inernational College of Neuropsychopharmacology) 2018 World Congress (Neuropsychopharmacology: Meeting global challenges with Global Innovation). (VIENNA, Austria)
Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Tsuyoshi Miyakawa (2018.6.17)
“Decreased brain pH in patients with depression and in a social defeat mouse model”
AINI 2018 (Advances in Neuroinformatics) (6th INCF Japan Node International Workshop) (和光市広沢)
Tsuyoshi Miyakawa, Akira Sato
Organized Session “Large Scale Mouse Brain Data”
Tsuyoshi Miyakawa
“Endophenotype in the brain: A key concept for understanding the relationships between genes and behavior”
2. 2018年11月1-2日
Molecular and Cellular Cognition Society (MCCS) 17th Annual Symposium (San Diego, CA)
Tomoyuki Murano, Tsuyoshi Miyakawa
“Spatial and Speed Information are differentially encoded in the Population Activity of Dentate Gyrus Neurons”
3. 2018年10月2-5日
The 13th International Conference of Neurons and Brain Diseases, AND meeting (Taipei, Taiwan)
Tsuyoshi Miyakawa
“Short-and long-term dematuration and its molecular mechanisms.”
Hirotaka Shoji, Keizo Takao, Satoko Hattori, Tsuyoshi Miyakawa（2018.10.3）
“Age-related behavioral changes from young adulthood to middle age in C57BL/6J mice”
4. 2018年9月25-28日
Cold Spring Harbor Asia meeting on Latest Advances in Development & Function of Neuronal Circuits (CSHL) （淡路夢舞台カンファレンスセンター、兵庫県）
Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo (2018.9.26)
“DNA polymerase β is required for postnatal hippocampal development and function.”
Tomoyuki Murano
“Spatial and Speed Information are differentially coded in Population Activity of Dentate Gyrus Neurons”
5. 2018年8月26-28日
2nd Pain and Emotion Summer Meeting, Association for the Study of Neurons and Diseases (ASND) (Toronto, Canada)
Tsuyoshi Miyakawa (2018.8.26)
“Decreased pH and increased lactate in the brains of animal models of depression.”
6. 2018年6月16-19日
CINP (The Inernational College of Neuropsychopharmacology) 2018 World Congress (Neuropsychopharmacology: Meeting global challenges with Global Innovation). (VIENNA, Austria)
Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Tsuyoshi Miyakawa (2018.6.17)
“Decreased brain pH in patients with depression and in a social defeat mouse model”
学会発表（国内）6件
1. 2019年3月27-29日
第124回 日本解剖学会総会・全国学術集会 （朱鷺メッセ新潟コンベンションセンター 新潟市中央区）
深澤元晶、服部聡子、宮川剛、石嶺久子、臼田信光
「β2-microgloblin欠損マウスの網羅的行動解析」
2. 2019年3月１-2日
第10回日本安全性薬理研究学術年会
Tsuyoshi Miyakawa
“Investigating gene-to-behavior pathways in genetically engineered mice by using a comprehensive behavioral test battery”
3. 2018月12月1-2日
日本基礎心理学学会大会（神奈川県川崎市 専修大学生田キャンパス）
宮川 剛
「脳内中間表現型：遺伝子と行動をつなぐためのキーコンセプト」
4. 2018年11月28-30日
第41回 日本分子生物学会年会 （パシフィコ横浜 神奈川県横浜市）
Kaori Ishikawa, Satoshi Yamamoto, Satoko Hattori, Naoya Nishimura, Takayuki Mito, Hirokazu Matsumoto, Tsuyoshi Miyakawa Kazuto Nakada.
“Progressive neurodegeneration and abnormal behavior were caused by acquired expression of mutant Mitofusin 2 in neurons.”
5. 2018年11月14-16日
第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会（東京ドームホテル 東京都文京区）
宮川剛
「Neuropsychopharmacology Reports; オープンサイエンス時代の理想の学会誌を目指して」
6. 2018年７月26-29日
第41回日本神経科学大会 （神戸コンベンションセンター 兵庫県）
Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Tsuyoshi Miyakawa （218.7.27）
“Decreased brain pH in patients with depression and in a social defeat mouse model”
Poster
昌子浩孝、中尾章人、宮川剛（7月26日）
「C57BL/6Jマウスにおける聴覚性驚愕反応とプレパルス抑制のメタ分析による関係把握」
第124回 日本解剖学会総会・全国学術集会 （朱鷺メッセ新潟コンベンションセンター 新潟市中央区）
深澤元晶、服部聡子、宮川剛、石嶺久子、臼田信光
「β2-microgloblin欠損マウスの網羅的行動解析」
2. 2019年3月１-2日
第10回日本安全性薬理研究学術年会
Tsuyoshi Miyakawa
“Investigating gene-to-behavior pathways in genetically engineered mice by using a comprehensive behavioral test battery”
3. 2018月12月1-2日
日本基礎心理学学会大会（神奈川県川崎市 専修大学生田キャンパス）
宮川 剛
「脳内中間表現型：遺伝子と行動をつなぐためのキーコンセプト」
4. 2018年11月28-30日
第41回 日本分子生物学会年会 （パシフィコ横浜 神奈川県横浜市）
Kaori Ishikawa, Satoshi Yamamoto, Satoko Hattori, Naoya Nishimura, Takayuki Mito, Hirokazu Matsumoto, Tsuyoshi Miyakawa Kazuto Nakada.
“Progressive neurodegeneration and abnormal behavior were caused by acquired expression of mutant Mitofusin 2 in neurons.”
5. 2018年11月14-16日
第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会（東京ドームホテル 東京都文京区）
宮川剛
「Neuropsychopharmacology Reports; オープンサイエンス時代の理想の学会誌を目指して」
6. 2018年７月26-29日
第41回日本神経科学大会 （神戸コンベンションセンター 兵庫県）
Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Tsuyoshi Miyakawa （218.7.27）
“Decreased brain pH in patients with depression and in a social defeat mouse model”
Poster
昌子浩孝、中尾章人、宮川剛（7月26日）
「C57BL/6Jマウスにおける聴覚性驚愕反応とプレパルス抑制のメタ分析による関係把握」
