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トップページ >  事業成果 >  2018年度成果発表 >  医療科学部 病態制御解析学/先進診断システム探索研究部門

医療科学部 病態制御解析学/先進診断システム探索研究部門


発表論文 38件

1. Tran, H. Q., Shin, E. J., Hoai Nguyen, B. C., Phan, D. H., Kang, M. J., Jang, C. G., Jeong, J. H., Nah, S. Y., Mouri, A., Saito, K., Nabeshima, T., and Kim, H. C. (2019) 5-HT1A receptor agonist 8-OH-DPAT induces serotonergic behaviors in mice via interaction between PKCdelta and p47phox. Food Chem Toxicol 123, 125-141

2. Teramoto, A., Tsujimoto, M., Inoue, T., Tsukamoto, T., Imaizumi, K., Toyama, H., Saito, K., and Fujita, H. (2019) Automated classification of pulmonary nodules through a retrospective analysis of conventional CT and two-phase PET images in patients undergoing biopsy. Asia Ocean J Nucl Med Biol 7, 29-37

3. Tanaka, S., Oya-Ito, T., Murakami, Y., Saito, K., Furuta, S., Yu, Y., Imaeda, M., Kunimoto, S., and Ozaki, N. (2019) Decline of plasma concentrations of Interleukin-18 in severely malnourished patients with anorexia nervosa: Exploratory analysis. Nutrients 11

4. Shin, E. J., Dang, D. K., Hwang, Y. G., Tran, H. Q., Sharma, N., Jeong, J. H., Jang, C. G., Nah, S. Y., Nabeshima, T., Yoneda, Y., Cadet, J. L., and Kim, H. C. (2019) Significance of protein kinase C in the neuropsychotoxicity induced by methamphetamine-like psychostimulants. Neurochem Int 124, 162-170

5. Shimizu, C., Wakita, Y., Inoue, T., Hiramitsu, M., Okada, M., Mitani, Y., Segawa, S., Tsuchiya, Y., and Nabeshima, T. (2019) Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1). Sci Rep 9, 3671

6. Sharma, N., Shin, E. J., Kim, N. H., Cho, E. H., Jeong, J. H., Jang, C. G., Nah, S. Y., Nabeshima, T., Yoneda, Y., Cadet, J. L., and Kim, H. C. (2019) Protective potentials of far-infrared ray against neuropsychotoxic conditions. Neurochem Int 122, 144-148

7. Onishi, Y., Teramoto, A., Tsujimoto, M., Tsukamoto, T., Saito, K., Toyama, H., Imaizumi, K., and Fujita, H. (2019) Automated pulmonary nodule classification in computed tomography images using a deep convolutional neural network trained by generative adversarial networks. Biomed Res Int 2019, 6051939

8. Nguyen, B. T., Sharma, N., Shin, E. J., Jeong, J. H., Lee, S. H., Jang, C. G., Nah, S. Y., Nabeshima, T., Yoneda, Y., and Kim, H. C. (2019) Theanine attenuates memory impairments induced by klotho gene depletion in mice. Food Funct 10, 325-332

9. Mai, H. N., Nguyen, L. T. T., Shin, E. J., Kim, D. J., Jeong, J. H., Chung, Y. H., Lei, X. G., Sharma, N., Jang, C. G., Nabeshima, T., and Kim, H. C. (2019) Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling. Free Radic Biol Med 131, 408-431

10. Kawaguchi, K., Sakurai, M., Yamamoto, Y., Suzuki, E., Tsuda, M., Kataoka, T. R., Hirata, M., Nishie, M., Nojiri, T., Kumazoe, M., Saito, K., and Toi, M. (2019) Alteration of specific cytokine expression patterns in patients with breast cancer. Sci Rep 9, 2924

11. Hasegawa, S., Yoshimi, A., Mouri, A., Uchida, Y., Hida, H., Mishina, M., Yamada, K., Ozaki, N., Nabeshima, T., and Noda, Y. (2019) Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Neuropharmacology 148, 107-116

12. Fujigaki, H., Mouri, A., Yamamoto, Y., Nabeshima, T., and Saito, K. (2019) Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia. Neurochem Int 125, 1-6

13. Alkam, T., and Nabeshima, T. (2019) Molecular mechanisms for nicotine intoxication. Neurochem Int 125, 117-126

14. Yamazaki, M., Yamada, H., Munetsuna, E., Ishikawa, H., Mizuno, G., Mukuda, T., Mouri, A., Nabeshima, T., Saito, K., Suzuki, K., Hashimoto, S., and Ohashi, K. (2018) Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter. FASEB J 32, 2549-2562

15. Yamamoto, Y., Yamasuge, W., Imai, S., Kunisawa, K., Hoshi, M., Fujigaki, H., Mouri, A., Nabeshima, T., and Saito, K. (2018) Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling. Sci Rep 8, 15917

16. Yamada, S., Itoh, N., Nagai, T., Nakai, T., Ibi, D., Nakajima, A., Nabeshima, T., and Yamada, K. (2018) Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. J Neuroinflammation 15, 295

17. Wulaer, B., Nagai, T., Sobue, A., Itoh, N., Kuroda, K., Kaibuchi, K., Nabeshima, T., and Yamada, K. (2018) Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1(Delta2-3/Delta2-3) mice. Genes Brain Behav 17, e12478

18. Tran, T. V., Shin, E. J., Nguyen, L. T. T., Lee, Y., Kim, D. J., Jeong, J. H., Jang, C. G., Nah, S. Y., Toriumi, K., Nabeshima, T., Yamada, K., and Kim, H. C. (2018) Protein kinase Cdelta gene depletion protects against methamphetamine-induced impairments in recognition memory and ERK1/2 signaling via upregulation of glutathione peroxidase-1 gene. Mol Neurobiol 55, 4136-4159

19. Tran, T. V., Park, S. J., Shin, E. J., Tran, H. Q., Jeong, J. H., Jang, C. G., Lee, Y. J., Nah, S. Y., Nabeshima, T., and Kim, H. C. (2018) Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-kappaB. Brain Res Bull 137, 71-78

20. Tran, H. Q., Park, S. J., Shin, E. J., Tran, T. V., Sharma, N., Lee, Y. J., Jeong, J. H., Jang, C. G., Kim, D. J., Nabeshima, T., and Kim, H. C. (2018) Clozapine attenuates mitochondrial burdens and abnormal behaviors elicited by phencyclidine in mice via inhibition of p47 (phox); Possible involvements of phosphoinositide 3-kinase/Akt signaling. J Psychopharmacol 32, 1233-1251

21. Tran, H. Q., Lee, Y., Shin, E. J., Jang, C. G., Jeong, J. H., Mouri, A., Saito, K., Nabeshima, T., and Kim, H. C. (2018) PKCdelta knockout mice are protected from dextromethorphan-induced serotonergic behaviors in mice: involvements of downregulation of 5-HT1A receptor and upregulation of Nrf2-dependent GSH synthesis. Mol Neurobiol 55, 7802-7821

22. Toriumi, K., Tanaka, J., Mamiya, T., Alkam, T., Kim, H. C., Nitta, A., and Nabeshima, T. (2018) Shati/Nat8l knockout mice show behavioral deficits ameliorated by atomoxetine and methylphenidate. Behav Brain Res 339, 207-214

23. Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksic, B., Aoyama, Y., Mori, D., Arioka, Y., Kawano, N., Yamamoto, M., Hattori, M., Nabeshima, T., Yamada, K., and Ozaki, N. (2018) Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. Sci Rep 8, 13046

24. Sobue, A., Ito, N., Nagai, T., Shan, W., Hada, K., Nakajima, A., Murakami, Y., Mouri, A., Yamamoto, Y., Nabeshima, T., Saito, K., and Yamada, K. (2018) Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. Glia 66, 1034-1052

25. Shin, E. J., Tran, H. Q., Nguyen, P. T., Jeong, J. H., Nah, S. Y., Jang, C. G., Nabeshima, T., and Kim, H. C. (2018) Role of mitochondria in methamphetamine-induced dopaminergic neurotoxicity: involvement in oxidative stress, neuroinflammation, and pro-apoptosis-A review. Neurochem Res 43, 66-78

26. Shin, E. J., Hwang, Y. G., Sharma, N., Tran, H. Q., Dang, D. K., Jang, C. G., Jeong, J. H., Nah, S. Y., Nabeshima, T., and Kim, H. C. (2018) Role of protein kinase Cd in dopaminergic neurotoxic events. Food Chem Toxicol 121, 254-261

27. Shimizu, C., Mitani, Y., Tsuchiya, Y., and Nabeshima, T. (2018) Effects of oral calcium dosage and timing on ethanol-induced sensitization of locomotion in DBA/2 mice. Biol Pharm Bull 41, 1049-1061

28. Shan, W., Nagai, T., Tanaka, M., Itoh, N., Furukawa-Hibi, Y., Nabeshima, T., Sokabe, M., and Yamada, K. (2018) Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. J Neurochem 145, 19-33

29. Nguyen, P. T., Shin, E. J., Dang, D. K., Tran, H. Q., Jang, C. G., Jeong, J. H., Lee, Y. J., Lee, H. J., Lee, Y. S., Yamada, K., Nabeshima, T., and Kim, H. C. (2018) Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochem Int 113, 69-84

30. Mouri, A., Ukai, M., Uchida, M., Hasegawa, S., Taniguchi, M., Ito, T., Hida, H., Yoshimi, A., Yamada, K., Kunimoto, S., Ozaki, N., Nabeshima, T., and Noda, Y. (2018) Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. Neuropharmacology 133, 23-37

31. Mai, H. N., Sharma, N., Shin, E. J., Nguyen, B. T., Nguyen, P. T., Jeong, J. H., Jang, C. G., Cho, E. H., Nah, S. Y., Kim, N. H., Nabeshima, T., and Kim, H. C. (2018) Exposure to far-infrared rays attenuates methamphetamine-induced recognition memory impairment via modulation of the muscarinic M1 receptor, Nrf2, and PKC. Neurochem Int 116, 63-76

32. Mai, H. N., Sharma, N., Shin, E. J., Nguyen, B. T., Nguyen, P. T., Jeong, J. H., Cho, E. H., Lee, Y. J., Kim, N. H., Jang, C. G., Nabeshima, T., and Kim, H. C. (2018) Exposure to far-infrared ray attenuates methamphetamine-induced impairment in recognition memory through inhibition of protein kinase C d in male mice: Comparison with the antipsychotic clozapine. J Neurosci Res 96, 1294-1310

33. Mai, H. N., Sharma, N., Shin, E. J., Nguyen, B. T., Jeong, J. H., Jang, C. G., Cho, E. H., Nah, S. Y., Kim, N. H., Nabeshima, T., and Kim, H. C. (2018) Exposure to far infrared ray protects methamphetamine-induced behavioral sensitization in glutathione peroxidase-1 knockout mice via attenuating mitochondrial burdens and dopamine D1 receptor activation. Neurochem Res 43, 1118-1135

34. Mai, H. N., Chung, Y. H., Shin, E. J., Sharma, N., Jeong, J. H., Jang, C. G., Saito, K., Nabeshima, T., Reglodi, D., and Kim, H. C. (2018) IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings. Food Chem Toxicol 116, 249-263

35. Hasegawa, S., Miyake, Y., Yoshimi, A., Mouri, A., Hida, H., Yamada, K., Ozaki, N., Nabeshima, T., and Noda, Y. (2018) Dysfunction of serotonergic and dopaminergic neuronal systems in the antidepressant-resistant impairment of social behaviors induced by social defeat stress exposure as juveniles. Int J Neuropsychopharmacol 21, 837-846

36. Dang, D. K., Shin, E. J., Kim, D. J., Tran, H. Q., Jeong, J. H., Jang, C. G., Ottersen, O. P., Nah, S. Y., Hong, J. S., Nabeshima, T., and Kim, H. C. (2018) PKCd-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity. Free Radic Biol Med 115, 318-337

37. Chiou, L. C., Lee, H. J., Ernst, M., Huang, W. J., Chou, J. F., Chen, H. L., Mouri, A., Chen, L. C., Treven, M., Mamiya, T., Fan, P. C., Knutson, D. E., Witzigmann, C., Cook, J., Sieghart, W., and Nabeshima, T. (2018) Cerebellar alpha6 -subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. Br J Pharmacol 175, 2414-2427

38. Bin Saifullah, M. A., Nagai, T., Kuroda, K., Wulaer, B., Nabeshima, T., Kaibuchi, K., and Yamada, K. (2018) Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice. Sci Rep 8, 14413