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Organization: Fujita Health University School of Medicine
NAMEF Department of Biochemistry
E-Mail: biochem@fujita-hu.ac.jp
HomePage: http://www.fujita-hu.ac.jp/~biochem/

ProfessorNobuhiro Harada
LecturerSatoru Ishihara
Assistant Eiji Munetsuna
Assistant Emi Sasaki

History of laboratory
The 1st department of biochemistry in the school of medicine, Fujita Health University was opened on 1974 by Dr. Isao Ishiguro, and succeeded on 1998 by Dr. Nobuhiro Harada. Since the graduate course was established on 1978, 11 graduate students completed and received a degree in medicine (a doctor of medicine), and furthermore 8 reserch fellows also received it.

Educational activities
Biochemistry has been given to the 1st-2nd grade medical students as a lecture and apprenticeship. The final goal in the biochemistry classes is that they come to comprehend well structures and functions of constituent elements in our body and pathways, regulation, and disorders of biomolecular metabolism. We positively take partial charge of classes of "Human Biology" and "Reading Seminar", conducted as a "small group learning"-type class.

Research activities
The research in this laboratory has been concentrated mainly on the biochemical, molecular endocrinological, molecular biological, and molecular genetical analyses of aromatase/estrogen-system. By these analyses, we expect that we would be bale to define a strong association of aromatase/estrogen-system with aging-related disorders, such as osteoporosis, arteriosclerosis, dementia of Alzheimer type, and so on, or with carcinogenesis of estrogen-dependent breast cancers or endometrial cancers. So, we have been analyzing dynamics and physiological functions of intracellular metablosim of estrogen and its precursor steroids, and transcriptional regulation of estrogen-metablizing enzymes (aromatase, steroid sulfatase, estrogen sulfotransferase, and 17beta-hydroxysteroid dehydrogenases 1- and 2-types), intracellular estrogen-signal transducing enzymes (estrogen receptors alpha and beta, ErbB2, and cyclin D1), and an estrogen-metabolic activating enzyme (Cyp1B1). Recently, we have successfully prepared aromatase knockout (ArKO) and estrogen-metabolizing enzymes transgenic mice. These embryo engineering animals has been used to study about participation of brain
aromatase in sexual differentiation of brain and regulation of sexual behaviors through neuroendocrinological and neurobehavioral analyses, and about transcriptional regulation of cell-specific, region-specific, and stage-speciific expression of brain aromatase through neuromolecular biological analysis. We have also been collaborating with clinical laboraories on the biochemical and molecular epidemiological analyses of pathogenetic factors of breast cancers and on the genetic diagnosis of congenital endocrinological disorders.

Tue May 7 23:47:19 JST 2013

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