Researcher Database
Name： Hidehito Inagaki

E-Mail address： hinagaki@fujita-hu.ac.jp

Organization / Department (#1)

Organization-1： Fujita Health University

Department(1) 1： Institute for Comprehensive Medical Science

Department(2) 1： Division of Molecular Genetics

Position-1： Assistant Professor

Address-1： 1-98,Toyoake aichi JAPAN

Academic Meeting / Research Meeting (#1)

Academic Meeting-1： The Molecular Biology Society of Japan

Academic Meeting / Research Meeting (#2)

Academic Meeting-2： The Japan Society of Human Genetics

Research History [2005] (#12)

Papers-12： Inagaki, H., Ohye, T., Kogo, H., Yamada, K., Kowa, H., Shaikh, T.H., Emanuel, B.S., Kurahashi, H. (2005). A palindromic AT-rich repeat in the NF1 gene is hypervariable in humans and evolutionarily conserved among primates. Hum. Mutat., 26, 332-342.

Speaker-12： Ohye, T., Inagaki, H., Kogo, H., Emanuel, B.S., Kurahashi, H. (2005). Yeast model system reveals the mechanism of palindrome-mediated chromosomal translocation. 55th annual meeting of American Society of Human Genetics, Salt Lake, USA, October, 25-29.
Kato, T., Inagaki, H., Yamada, K., Kogo, H., Ohye, T., Emanuel, B.S., Kurahashi, H. (2005). Polymorphism of the palindromic sequence at the 11q23 breakpoint region affects de novo t(11;22) translocation frequency. 55th Annual Meeting of American Society of Human Genetics, Salt Lake City, USA, October, 25-29.

Research History [2006] (#13)

Papers-13： Kato, T., Inagaki, H., Yamada, K., Kogo, H., Ohye, T., Kowa, H., Nagaoka, K., Taniguchi, M., Emanuel, B.S., Kurahashi, H. (2006) Genetic variation affects de novo translocation frequency. Science, 311, 971.
Kurahashi, H., Inagaki, H., Kogo, H., Ohye, T., Kato, T., Emanuel, B.S. (2006). Chromosomal translocation mediated by palindromic DNA. Cell Cycle, 5, 1297-1303.
Ashley, T., Gaeth, A.P., Inagaki, H., Seftel, A., Cohen, M.M., Anderson, L., Kurahashi, H., Emanuel, B.S. (2006). Meiotic recombination and spatial proximity in the ethiology of the recurrent t(11;22). Am. J. Hum. Genet., 79, 524-538.
Kurahashi, H., Inagaki, H., Kogo, H., Ohye, T., Kato, T., Emanuel, B.S. (2006). Palindrome-mediated chromosomal translocations in humans. DNA Repair, 5, 1136-1145.

Speaker-13： Inagaki, H., Ohye, T., Kogo, H., Emanuel, B.S., Kurahashi, H. (2006).
A two-step mechanism for palindrome-mediated rearrangements in human cells. 20th IUBMB International Congress of Biochemistry and Molecular Biology, Kyoto, Japan, June, 18-23.
Inagaki, H., Ohye, T., Kogo, H., Emanuel, B.S., Kurahashi, H. (2006).
A two-step mechanism for palindrome-mediated rearrangements in human
Cell. 11th International Congress of Human Genetics, Brisbane, Australia, August, 6-10.
Inagaki, H., Ohye, T., Kogo, H., Emanuel, B.S., Kurahashi, H. (2006).
Not sequence, but structure: palindrome-mediated translocation. 56th annual meeting of American Society of Human Genetics, New Orleans, USA, October 9-13.

Research History [2007] (#14)

Papers-14： Kogo, H., Inagaki, H., Ohye, T., Kato, T., Emanuel, B.S., Kurahashi, H. (2007). Cruciform extrusion propensity of human translocation-mediating palindromic AT-rich repeats. Nucleic Acids Res., 35, 1198-1208.
Kurahashi, H., Inagaki, H., Hosoba, E., Kato, T., Ohye, T., Kogo, H., Emanuel, B.S. (2007). Molecular cloning of a translocation breakpoint hotspot in 22q11. Genome Res., 17, 461-469.
Kato, T., Yamada, K., Inagaki, H., Kogo, H., Ohye, T., Emanuel, B.S., Kurahashi, H. (2007). Age has no effect on de novo constitutional t(11;22) translocation frequency in sperm. Fertil. Steril., 88, 1446-1448.

Research History [2008] (#15)

Papers-15： Kato, T., Inagaki, H., Kogo, H., Ohye, T., Yamada, K., Emanuel, B.S., Kurahashi, H. (2008) Two different forms of palindrome resolution in the human genome: deletion or translocation. Hum. Mol. Genet., 17, 1184-1191.

Speaker-15： Inagaki, H., Ohye, T., Kogo, H., Kato, T., Tong, M., Tsutsumi, M., Emanuel, B.S., Kurahashi, H. (2008). Artemis cleaves cruciform-forming palindromic DNA leading to recurrent translocation in humans. The 6th 3R Symposium, Kakegawa, Japan, October, 27-30.
Inagaki, H., Ohye, T., Kogo, H., Kato, T., Tong, M., Tsutsumi, M., Emanuel., B.S., Kurahashi, H. (2008). Artemis cleaves cruciform-forming palindromic DNA leading to recurrent translocation in humans. ASHG Ataxia-Telangiectasia/Genome Instability Satellite Meeting, Philadelphia, USA, November, 11.
Inagaki, H., Ohye, T., Kogo, H., Kato, T., Tong, M., Tsutsumi, M., Emanuel., B.S., Kurahashi, H. (2008). Artemis cleaves cruciform-forming palindromic DNA leading to recurrent translocation in humans. 58th annual meeting of American Society of Human Genetics, Philadelphia, USA, November, 11-15.

Research History [2009] (#16)

Papers-16： Inagaki, H., Ohye, T., Kogo, H., Kato, T., Bolor, H., Taniguchi, M., Shaikh, T.H., Emanuel, B.S., Kurahashi, H. (2009) Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence ins responsible for recurrent translocation in humans. Genome Res., 19, 191-198.
olor, H., Mori, T., Nishiyama, S., Ito, Y., Hosoba, E., Inagaki, H., Kogo, H., Ohye, T., Tsutsumi, M., Kato, T., Tong, M., Nishizawa, H., Pryor-Koishi, K., Kitaoka, E., Sawada, T., Nishiyama, Y., Udagawa, Y., Kurahashi, H. (2009) Mutations of the SYCP3 gene in women with recurrent pregnancy loss. Am. J. Hum. Genet., 84, 14-20.
3. Kurahashi, H., Bolor, H., Kato, T., Kogo, H., Tsutsumi, M., Inagaki, H., Ohye, T. Recent advance in our understanding of the molecular nature of chromosomal abnormalities. J. Hum. Genet., 54, 253-260.
4. Kurahashi, H., Inagaki, H., Kato, T., Hosoba, E., Kogo, H., Ohye, T., Tsutsumi, M., Bolor, H., Tong, M., Emanuel, B.S. (2009) Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells. Hum. Mol. Genet., 18, 3397-3406.

Research History [2010] (#17)

Papers-17： Kurahashi H, Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel B. The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements. Clin Genet. 2010 Oct;78(4):299-309.
Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MV, Medne L, Zackai EH, Emanuel BS, Kurahashi H. Paternal origin of the de novo constitutional t(11;22)(q23;q11). Eur J Hum Genet. 2010 Jul;18(7):783-7.
Tong M, Kato T, Yamada K, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Wang J, Emanuel BS, Kurahashi H. Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm. Hum Mol Genet. 2010 Jul 1;19(13):2630-7.

Speaker-17： Hidehito Inagaki, Tamae Ohye, Hiroshi Kogo, Makiko Tsutsumi, Takema Kato, Maoqing Tong, Beverly S. Emanuel, and Hiroki Kurahashi. GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. 60th Annual Meeting of The American Society of Human Genetics. Nov. 2-6, 2010. Washington D.C., USA.
Hidehito Inagaki, Tamae Ohye, Hiroshi Kogo, Makiko Tsutsumi, Takema Kato, Maoqing Tong, Beverly S. Emanuel, and Hiroki Kurahashi. Analysis of mechanism of t(11;22) by using two plasmid system in human cell. The 55th meeting of The Japan Society of Human Genetics. Oct 27-30, 2010, Saitama.
Hidehito Inagaki, Tamae Ohye, Hiroshi Kogo, Makiko Tsutsumi, Takema Kato, Maoqing Tong, Beverly S. Emanuel, and Hiroki Kurahashi. GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. The 7th 3R Symposium. Oct. 26-30, 2010. Toyama.

Fri Nov 19 17:36:30 JST 2010

Researcher Database
Name：	Hidehito Inagaki
E-Mail address：	hinagaki@fujita-hu.ac.jp

Organization / Department (#1)
Organization-1：	Fujita Health University
Department(1) 1：	Institute for Comprehensive Medical Science
Department(2) 1：	Division of Molecular Genetics
Position-1：	Assistant Professor
Address-1：	1-98,Toyoake aichi JAPAN

Academic Meeting / Research Meeting (#1)
Academic Meeting-1：	The Molecular Biology Society of Japan
Academic Meeting / Research Meeting (#2)
Academic Meeting-2：	The Japan Society of Human Genetics

Research History [2005] (#12)
Papers-12：	Inagaki, H., Ohye, T., Kogo, H., Yamada, K., Kowa, H., Shaikh, T.H., Emanuel, B.S., Kurahashi, H. (2005). A palindromic AT-rich repeat in the NF1 gene is hypervariable in humans and evolutionarily conserved among primates. Hum. Mutat., 26, 332-342.
Speaker-12：	Ohye, T., Inagaki, H., Kogo, H., Emanuel, B.S., Kurahashi, H. (2005). Yeast model system reveals the mechanism of palindrome-mediated chromosomal translocation. 55th annual meeting of American Society of Human Genetics, Salt Lake, USA, October, 25-29. Kato, T., Inagaki, H., Yamada, K., Kogo, H., Ohye, T., Emanuel, B.S., Kurahashi, H. (2005). Polymorphism of the palindromic sequence at the 11q23 breakpoint region affects de novo t(11;22) translocation frequency. 55th Annual Meeting of American Society of Human Genetics, Salt Lake City, USA, October, 25-29.
Research History [2006] (#13)
Papers-13：	Kato, T., Inagaki, H., Yamada, K., Kogo, H., Ohye, T., Kowa, H., Nagaoka, K., Taniguchi, M., Emanuel, B.S., Kurahashi, H. (2006) Genetic variation affects de novo translocation frequency. Science, 311, 971. Kurahashi, H., Inagaki, H., Kogo, H., Ohye, T., Kato, T., Emanuel, B.S. (2006). Chromosomal translocation mediated by palindromic DNA. Cell Cycle, 5, 1297-1303. Ashley, T., Gaeth, A.P., Inagaki, H., Seftel, A., Cohen, M.M., Anderson, L., Kurahashi, H., Emanuel, B.S. (2006). Meiotic recombination and spatial proximity in the ethiology of the recurrent t(11;22). Am. J. Hum. Genet., 79, 524-538. Kurahashi, H., Inagaki, H., Kogo, H., Ohye, T., Kato, T., Emanuel, B.S. (2006). Palindrome-mediated chromosomal translocations in humans. DNA Repair, 5, 1136-1145.
Speaker-13：	Inagaki, H., Ohye, T., Kogo, H., Emanuel, B.S., Kurahashi, H. (2006). A two-step mechanism for palindrome-mediated rearrangements in human cells. 20th IUBMB International Congress of Biochemistry and Molecular Biology, Kyoto, Japan, June, 18-23. Inagaki, H., Ohye, T., Kogo, H., Emanuel, B.S., Kurahashi, H. (2006). A two-step mechanism for palindrome-mediated rearrangements in human Cell. 11th International Congress of Human Genetics, Brisbane, Australia, August, 6-10. Inagaki, H., Ohye, T., Kogo, H., Emanuel, B.S., Kurahashi, H. (2006). Not sequence, but structure: palindrome-mediated translocation. 56th annual meeting of American Society of Human Genetics, New Orleans, USA, October 9-13.
Research History [2007] (#14)
Papers-14：	Kogo, H., Inagaki, H., Ohye, T., Kato, T., Emanuel, B.S., Kurahashi, H. (2007). Cruciform extrusion propensity of human translocation-mediating palindromic AT-rich repeats. Nucleic Acids Res., 35, 1198-1208. Kurahashi, H., Inagaki, H., Hosoba, E., Kato, T., Ohye, T., Kogo, H., Emanuel, B.S. (2007). Molecular cloning of a translocation breakpoint hotspot in 22q11. Genome Res., 17, 461-469. Kato, T., Yamada, K., Inagaki, H., Kogo, H., Ohye, T., Emanuel, B.S., Kurahashi, H. (2007). Age has no effect on de novo constitutional t(11;22) translocation frequency in sperm. Fertil. Steril., 88, 1446-1448.
Research History [2008] (#15)
Papers-15：	Kato, T., Inagaki, H., Kogo, H., Ohye, T., Yamada, K., Emanuel, B.S., Kurahashi, H. (2008) Two different forms of palindrome resolution in the human genome: deletion or translocation. Hum. Mol. Genet., 17, 1184-1191.
Speaker-15：	Inagaki, H., Ohye, T., Kogo, H., Kato, T., Tong, M., Tsutsumi, M., Emanuel, B.S., Kurahashi, H. (2008). Artemis cleaves cruciform-forming palindromic DNA leading to recurrent translocation in humans. The 6th 3R Symposium, Kakegawa, Japan, October, 27-30. Inagaki, H., Ohye, T., Kogo, H., Kato, T., Tong, M., Tsutsumi, M., Emanuel., B.S., Kurahashi, H. (2008). Artemis cleaves cruciform-forming palindromic DNA leading to recurrent translocation in humans. ASHG Ataxia-Telangiectasia/Genome Instability Satellite Meeting, Philadelphia, USA, November, 11. Inagaki, H., Ohye, T., Kogo, H., Kato, T., Tong, M., Tsutsumi, M., Emanuel., B.S., Kurahashi, H. (2008). Artemis cleaves cruciform-forming palindromic DNA leading to recurrent translocation in humans. 58th annual meeting of American Society of Human Genetics, Philadelphia, USA, November, 11-15.
Research History [2009] (#16)
Papers-16：	Inagaki, H., Ohye, T., Kogo, H., Kato, T., Bolor, H., Taniguchi, M., Shaikh, T.H., Emanuel, B.S., Kurahashi, H. (2009) Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence ins responsible for recurrent translocation in humans. Genome Res., 19, 191-198. olor, H., Mori, T., Nishiyama, S., Ito, Y., Hosoba, E., Inagaki, H., Kogo, H., Ohye, T., Tsutsumi, M., Kato, T., Tong, M., Nishizawa, H., Pryor-Koishi, K., Kitaoka, E., Sawada, T., Nishiyama, Y., Udagawa, Y., Kurahashi, H. (2009) Mutations of the SYCP3 gene in women with recurrent pregnancy loss. Am. J. Hum. Genet., 84, 14-20. 3. Kurahashi, H., Bolor, H., Kato, T., Kogo, H., Tsutsumi, M., Inagaki, H., Ohye, T. Recent advance in our understanding of the molecular nature of chromosomal abnormalities. J. Hum. Genet., 54, 253-260. 4. Kurahashi, H., Inagaki, H., Kato, T., Hosoba, E., Kogo, H., Ohye, T., Tsutsumi, M., Bolor, H., Tong, M., Emanuel, B.S. (2009) Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells. Hum. Mol. Genet., 18, 3397-3406.
Research History [2010] (#17)
Papers-17：	Kurahashi H, Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel B. The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements. Clin Genet. 2010 Oct;78(4):299-309. Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MV, Medne L, Zackai EH, Emanuel BS, Kurahashi H. Paternal origin of the de novo constitutional t(11;22)(q23;q11). Eur J Hum Genet. 2010 Jul;18(7):783-7. Tong M, Kato T, Yamada K, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Wang J, Emanuel BS, Kurahashi H. Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm. Hum Mol Genet. 2010 Jul 1;19(13):2630-7.
Speaker-17：	Hidehito Inagaki, Tamae Ohye, Hiroshi Kogo, Makiko Tsutsumi, Takema Kato, Maoqing Tong, Beverly S. Emanuel, and Hiroki Kurahashi. GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. 60th Annual Meeting of The American Society of Human Genetics. Nov. 2-6, 2010. Washington D.C., USA. Hidehito Inagaki, Tamae Ohye, Hiroshi Kogo, Makiko Tsutsumi, Takema Kato, Maoqing Tong, Beverly S. Emanuel, and Hiroki Kurahashi. Analysis of mechanism of t(11;22) by using two plasmid system in human cell. The 55th meeting of The Japan Society of Human Genetics. Oct 27-30, 2010, Saitama. Hidehito Inagaki, Tamae Ohye, Hiroshi Kogo, Makiko Tsutsumi, Takema Kato, Maoqing Tong, Beverly S. Emanuel, and Hiroki Kurahashi. GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. The 7th 3R Symposium. Oct. 26-30, 2010. Toyama.