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Researcher Database
Name: Yoshitaka Iba
Keyword: antibody, influenza virus

Research Information (#1)
Research section-1: Virology, Immunology

Organization / Department (#1)
Organization-1: Fujita Health University
Department(1) 1: Institute for Comprehensive Medical Science
Department(2) 1: Division of antibody project
Position-1: Assistant Professor
Address-1: 1-98,Toyoake aichi JAPAN

Research History [Other] (#1)
Papers-1: Yoshitaka Iba, Kousaku Murata and Akira Kimura, 1988. g -Glutamylcysteine Synthetase in Escherichia coli B Contains No Active SiteThiol. Agric. Biol. Chem.52, 2633-2634.

Kousaku Murata, Yoshitaka Iba, Yoshiharu Inoue and Akira Kimura, 1988. L-Leucine and its Analogue : Specific Inhibitors for s -Benzyl-L-Cysteine-p-Nitroanilide-Hydrolyzing Enzyme in Escherichia coli B. Biochem. Biophys. Res. Commun. 153, 767-772.

Takashi Kaneko, Yoshitaka Iba, Koichi Zenita, Katsuyoshi Shigeta, Koichi Nakano, Wataru Itoh, Yoshikazu Kurosawa, Reiji Kannagi and Kiyoshi Yasukawa, 1993. Preparation of Mouse-Human Chimeric Antibody to an Embryonic Carbohydrate Antigen, Lewis Y. J. Biochem. 113, 114-117.

Wataru Ito, Yoshitaka Iba and Yoshikazu Kurosawa, 1993. Effects of Substitutions of Closely Related Amino Acids at the Contact Surface in an Antigen-Antibody Complex on Thermodynamic Parameters. J. Biol. Chem. 268, 16639-16647.
Research History [1995] (#2)
Papers-2: Kiyoshi Yasukawa, Takashi Kaneko, Yoshitaka Iba, Koji Hirayama, Yasuyuki Kondo, Tetsuji Sawada, Michio Sowa, Jenny J. L. Ho, Young S. Kim and Yong-Suk Chung, 1995. Preparation of Mouse-Human Chimeric Antibody against Pancreatic Cancer-Associated Mucin. International Journal of Oncology 6, 1047-1051.

Yoshitaka Iba, Takashi Kaneko, Teiji Ekida, Kenji Miyata, Kuniyo Inouye, Yoshikazu Kurosawa and Kiyoshi Yasukawa, 1995. A New System for the Expression of Recombinant Antibody in Mammalian Cells. Biotechnology Letters 17, 135-138.

Kuniaki Takagi, Kiyoshi Yasukawa, Yoshitaka Iba, Yuji Isobe, Yasunobu Suketa, Reiji Kannagi, Katsunori Kohda, Masahiro Takagi and Tadayuki Imanaka, 1995. Expression of Recombinant Antibody against Cancer-Specific Carbohydrate. Journal of Fermentation and Bioengineering 79, 405-409.
Research History [1997] (#4)
Papers-4: Yoshitaka Iba, Wataru Ito and Yoshikazu Kurosawa, 1997. Expression vectors for the introduction of highly diverged sequences into the six complementarity-determining regions of an antibody. Gene 194, 35-46.

Yoshitaka Iba and Yoshikazu Kurosawa, 1997. Comparison of strategies for the construction of libraries of artificial antibodies. Immunology and Cell Biology 75, 217-221.
Research History [1998] (#5)
Papers-5: Yoshitaka Iba, Nobuhiro Hayashi, Jun-ichi Sawada, Koiti Titani and Yoshikazu Kurosawa, Changes in the specificity of antibodies against steroid antigens by introduction of mutations into complementarity-determining regions of the VH domain. Protein Engng. 11, 361-370 (1998).
Research History [1999] (#6)
Papers-6: Chie Miyazaki, Yoshitaka Iba, Yukio Yamada, Haruo Takahashi, Jun-ichi Sawada and Yoshikazu Kurosawa, Changes in the specificity of antibodies by site-specific mutagenesis followed by random mutagenesis. Protein Engng. 12, 407-415 (1999).
Research History [2001] (#8)
Papers-8: Kazuhiko Morino, Harue Katsumi, Yasushi Akahori, Yoshitaka Iba, Midori Shinohara, Yoshinori Ukai, Yuji Kohara and Yoshikazu Kurosawa, Antibody fusions with fluorescent proteins: a versatile reagent for profiling protein expression. J. Immunol. Methods 257, 175-184, 2001.
Research History [2002] (#9)
Papers-9: Yoshitaka Iba, Chie Miyazaki and Yoshikazu Kurosawa, Two-step strategy for alteration of immunoglobulin specificity by in vitro mutagenesis. Methods in Molecular Biology 178: Antibody Phage Display 259-267, 2002.

Akira Ideno, Masahiro Frutani, Yoshitaka Iba, Yoshikazu Kurosawa and Tadashi Maruyama, FK506 binding protein from the hyperthermophilic archaeon Pyrococcus horikoshii suppresses the aggregation of proteins in Escherichia coli. Applied and Environmental Microbiology, 68(2), 464-469, 2002.
Research History [2004] (#11)
Papers-11: Kyoko Higo-Moriguchi, Yasushi Akahori, Yoshitaka Iba, Yoshikazu Kurosawa and Koki Taniguchi, Isolation of human monoclonal antibodies that neutralize human rotavirus. Journal of Virology, 78 (7), 3325-3332, 2004.

A. Ideno, M. Frutani, T. Iwabuchi, T. Iida, Y. Iba, Y. Kurosawa, H. Sakuraba, T. Oshima, Y. Kawarabayashi and T. Maruyama, Expression of foreign proteins in Escherichia coli by fusing with an archaeal FK506 binding protein. Appl. Microbiol. Biotechnol., 64, 99-105, 2004.
Research History [2006] (#13)
Papers-13: Mai Kakita, Tsuyoshi Takahashi, Takako Komiya, Yoshitaka Iba, Takao Tsuji, Yoshikazu Kurosawa and Motohide Takahashi, Isolation of a Human Monoclonal Antibody with Strong Neutralizing Activity against Diphtheria Toxin. INFECTION AND IMMUNITY, 74 (6), 3682-3683, 2006.
Research History [2008] (#15)
Papers-15: Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic. Kurosawa G, Akahori Y, Morita M, Sumitomo M, Sato N, Muramatsu C, Eguchi K, Matsuda K, Takasaki A, Tanaka M, Iba Y, Hamada-Tsutsumi S, Ukai Y, Shiraishi M, Suzuki K, Kurosawa M, Fujiyama S, Takahashi N, Kato R, Mizoguchi Y, Shamoto M, Tsuda H, Sugiura M, Hattori Y, Miyakawa S, Shiroki R, Hoshinaga K, Hayashi N, Sugioka A, & Kurosawa Y. Proc. Natl. Acad. Sci. U. S. A. 2008 May 20;105(20):7287-92.
Research History [2009] (#16)
Papers-16: A. Ohta, A. Fujita, Y. Iba, Y. Kurosawa, T. Yoshikawa & Y. Asano. Recombinant human monoclonal antibodies to human cytomegalovirus glycoprotein B neutralize virus in a complement-dependent manner. Microbe Infect. 2009 Nov 11(13):1029-1036.

Gene Kurosawa, Mariko Sumitomo, Yasushi Akahori, Kazuki Matsuda, Chiho Muramatsu, Akihiko Takasaki, Yoshitaka Iba, Keiko Eguchi, Miho Tanaka, Kazuhiro Suzuki, Miwa Morita, Noriko Sato, Mototaka Sugiura, Atsushi Sugioka, Nobuhiro Hayashi & Yoshikazu Kurosawa. J. Immunol. Methods. 2009 Sep 18.

Yuka Kitamura, Gene Kurosawa, Miho Tanaka, Mariko Sumitomo, Chiho Muramatsu, Keiko Eguchi, Yasushi Akahori, Yoshitaka Iba, Hiroyuki Tsuda, Mototaka Sugiura, Yoshinobu Hattori & Yoshikazu Kurosawa. Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma. Biochem. Biophys. Res. Commun. 2009 Jun 12;383(4):480-4.

Yasushi Akahori, Gene Kurosawa, Mariko Sumitomo, Miwa Morita, Chiho Muramatsu, Keiko Eguchi, Miho Tanaka, Kazuhiro Suzuki, Mototaka Sugiura, Yoshitaka Iba, Atsushi Sugioka & Yoshikazu Kurosawa. Isolation of antigen/antibody complexes through organic solvent (ICOS) method. Methods for comprehensive identification of membrane proteins recognized by a large number of monoclonal antibodies. Biochem. Biophys. Res. Commun. 2009 Jan 23;378(4):832-5.
Research History [2010] (#17)
Papers-17: J. Okada, N. Ohshima, Ritsuko Kubota-Koketsu, Sayuri Ota, Wakana Takase, Masachika Azuma, Yoshitaka Iba, Naoko Nakagawa, Tetsushi Yoshikawa, Youichi Nakajima, Toyokazu Ishikawa, Yoshizo Asano, Yoshinobu Okuno & Yoshikazu Kurosawa. Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified into three groups with distinct strain specificity: 1968-73, 1977-93 and 1997-2003. Virology 397 (2010) 322・30.
Research History [2011] (#18)
Papers-18: Jun Okada, Nobuko Ohshima, Ritsuko Kubota-Koketsu,
Yoshitaka Iba, Sayuri Ota, Wakana Takase, Tetsushi Yoshikawa, Toyokazu Ishikawa, Yoshizo Asano, Yoshinobu Okuno and Yoshikazu Kurosawa. Localization of epitopes recognized by monoclonal antibodies that neutralized the H3N2 influenza viruses in man. Journal of General Virology (2011), 92, 326–335.

Nobuko Ohshima, Yoshitaka Iba, Ritsuko Kubota-Koketsu, Yoshizo Asano, Yoshinobu Okuno, and Yoshikazu Kurosawa. Naturally occurring antibodies in humans can neutralize a variety of influenza virus strains, including H3, H1, H2, and H5. Journal of Virology (2011), 85, in press.

Research History [2013] (#20)
Papers-20: Ohshima N., Kubota-Koketsu R., Iba Y., Okuno Y., Kurosawa Y., 2014. Two types of antibodies are induced by vaccination with A/California/2009pdm virus: binding near the sialic acid-binding pocket and neutralizing both H1N1 and H5N1 viruses. PLoS One 9:e87305, 1-10.

Mon Mar 10 09:54:42 JST 2014

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