Division of Antibody Project
Institute for Comprehensive Medical Science
Fujita Health University

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Publications

Arimitsu H, Sasaki K, Iba Y, Kurosawa Y, Shimizu T, Tsuji T, 2015. Isolation of B subunit-specific monoclonal antibody clones that strongly neutralize the toxicity of Shiga toxin 2.  Microbiol. Immunol. 59(2), 71-81.

Iba Y, Fujii Y, Ohshima N, Sumida T, Kubota-Koketsu R, Ikeda M, Wakiyama M, Shirouzu M, Okada J, Okuno Y, Kurosawa Y, Yokoyama S, 2014. Conserved neutralizing epitope at globular head of hemagglutinin in H3N2 influenza viruses. J. Virol. 88, 7130-7144.

Lee PS, Ohshima N, Stanfield RL, Yu W, Iba Y, Okuno Y, Kurosawa Y, Wilson IA, 2014. Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus. Nat. Commun. 5:3614. doi: 10.1038/ncomms4614.

Ohshima N, Kubota-Koketsu R, Iba Y, Okuno Y, Kurosawa Y, 2014. Two types of antibodies are induced by vaccination with A/California/2009pdm virus: binding near the sialic acid-binding pocket and neutralizing both H1N1 and H5N1 viruses. PLoS One 9:e87305, 1-10.

Ohshima N, Iba Y, Kubota-Koketsu R, Asano Y, Okuno Y, Kurosawa Y, 2011. Naturally occurring antibodies in humans can neutralize a variety of influenza virus strains, including H3, H1, H2, and H5. J. Virol. 85, 11048-11057.

Okada J, Ohshima N, Kubota-koketsu R, Iba Y, Ota S, Takase W, Yoshikawa T, Ishikawa T, Asano Y, Okuno Y, Kurosawa Y, 2011. Localization of epitopes recognized by monoclonal antibodies that neutralized the H3N2 influenza viruses in man. J. Gen. Virol. 92, 326-335.

Okada J, Ohshima N, Kubota-Koketsu R, Ota S, Takase W, Azuma M, Iba Y, Nakagawa N, Yoshikawa T, Nakajima Y, Ishikawa T, Asano Y, Okuno Y, Kurosawa Y, 2010. Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified in to three groups with distinct strain specificity: 1968-1973, 1977-1993 and 1997-2003. Virology 397, 322-330.

Kurosawa G, Sumitomo M, Akahori Y, Matsuda K, Muramatsu C, Takasaki A, Iba Y, Eguchi K, Tanaka M, Suzuki K, Morita M, Sato N, Sugiura M, Sugioka A, Hayashi N, Kurosawa Y, 2009. Methods for comprehensive identification of membrane proteins recognized by a large number of monoclonal antibodies. J. Immunol. Methods. 351, 1-12.

Ohta A, Fujita A, Iba Y, Kurosawa Y, Yoshikawa T, Asano Y, 2009. Recombinant human monoclonal antibodies to human cytomegalovirus glycoprotein B neutralize virus in a complement-dependent manner. Microbe Infect. 11, 1029-1036.

Kitamura Y, Kurosawa G, Tanaka M, Sumitomo M, Muramatsu C, Eguchi K, Akahori Y, Iba Y, Tsuda H, Sugiura M, Hattori Y, Kurosawa Y, 2009. Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma. Biochem. Biophys. Res. Commun. 383, 480-484.

Akahori Y, Kurosawa G, Sumitomo M, Morita M, Muramatsu C, Eguchi K, Tanaka M, Suzuki K, Sugiura M, Iba Y, Sugioka A, Kurosawa Y, 2009. Isolation of antigen/antibody complexes through organic solvent (ICOS) method. Biochem. Biophys. Res. Commun. 378, 832-835.

Kurosawa G, Akahori Y, Morita M, Sumitomo M, Sato N, Muramatsu C, Eguchi K, Matsuda K, Takasaki A, Tanaka M, Iba Y, Hamada-Tsutsumi S, Ukai Y, Shiraishi M, Suzuki K, Kurosawa M, Fujiyama S, Takahashi N, Kato R, Mizoguchi Y, Shamoto M, Tsuda H, Sugiura M, Hattori Y, Miyakawa S, Shiroki R, Hoshinaga K, Hayashi N, Sugioka A, Kurosawa Y, 2008. Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic. Proc. Natl. Acad. Sci. U. S. A. 105, 7287-92.

Kakita M, Takahashi T, Komiya T, Iba Y, Tsuji T, Kurosawa Y, Takahashi M, 2006. Isolation of a Human Monoclonal Antibody with Strong Neutralizing Activity against Diphtheria Toxin. Infect. Immun. 74, 3682-3683.

Higo-Moriguchi K, Akahori Y, Iba Y, Kurosawa Y, Taniguchi K, 2004. Isolation of human monoclonal antibodies that neutralize human rotavirus. J. Virol. 78, 3325-3332.

Ideno A, Furutani M, Iwabuchi T, Iida T, Iba Y, Kurosawa Y, Sakuraba H, Ohshima T, Kawarabayashi Y, Maruyama T, 2003. Expression of foreign proteins in Escherichia coli by fusing with an archaeal FK506 binding protein. Appl. Microbiol. Biotechnol. 64, 99-105.

Iba Y, Miyazaki C, Kurosawa Y, 2002. Two-step strategy for alteration of immunoglobulin specificity by in vitro mutagenesis. Methods Mol. Biol. 178: Antibody Phage Display 259-267. Review.

Ideno A, Furutani M, Iba Y, Kurosawa Y, Maruyama T, 2002. FK506 binding protein from the hyperthermophilic archaeon Pyrococcus horikoshii suppresses the aggregation of proteins in Escherichia coli. Appl. Environ. Microbiol. 68, 464-469.

Morino K, Katsumi H, Akahori Y, Iba Y, Shinohara M, Ukai Y, Kohara Y, Kurosawa Y, 2001. Antibody fusions with fluorescent proteins: a versatile reagent for profiling protein expression. J. Immunol. Methods 257, 175-184.

Miyazaki C, Iba Y, Yamada Y, Takahashi H, Sawada J, Kurosawa Y, 1999. Changes in the specificity of antibodies by site-specific mutagenesis followed by random mutagenesis. Protein Engng. 12, 407-415.

Iba Y, Hayashi N, Sawada J, Titani K, Kurosawa Y, 1998. Changes in the specificity of antibodies against steroid antigens by introduction of mutations into complementarity-determining regions of the VH domain. Protein Engng. 11, 361-370.

Iba Y, Kurosawa Y, 1997. Comparison of strategies for the construction of libraries of artificial antibodies. Immunol. Cell Biol. 75, 217-221. Review.

Iba Y, Ito W, Kurosawa Y, 1997. Expression vectors for the introduction of highly diverged sequences into the six complementarity-determining regions of an antibody. Gene 194, 35-46.

Yasukawa K, Kaneko T, Iba Y, Hirayama K, Kondo Y, Sawada T, Sowa M, Ho JJL, Kim YS, Chung YS, 1995. Preparation of Mouse-Human Chimeric Antibody against Pancreatic Cancer-Associated Mucin. Int. J. Oncol. 6, 1047-1051.

Iba Y, Kaneko T, Ekida T, Miyata K, Inouye K, Kurosawa Y, Yasukawa K, 1995. A New System for the Expression of Recombinant Antibody in Mammalian Cells. Biotechnol. Lett. 17, 135-138.

Takagi K, Yasukawa K, Iba Y, Isobe Y, Suketa Y, Kannagi R, Kohda K, Takagi M, Imanaka T, 1995. Expression of Recombinant Antibody against Cancer-Specific Carbohydrate. Journal of Fermentation and Bioengineering 79, 405-409.

Ito W, Iba Y, Kurosawa Y, 1993. Effects of substitution of closely related amino acids at the contact surface in an antigen-antibody complex on thermodynamic parameters. J. Biol. Chem. 268, 16639-16647.

Kaneko T, Iba Y, Zenita K, Shigeta K, Nakano K, Itoh W, Kurosawa Y, Kannagi R, Yasukawa K, 1993. Preparation of Mouse-Human Chimeric Antibody to an Embryonic Carbohydrate Antigen, Lewis Y. J. Biochem. 113, 114-117.

 


 Last Update : July 1, 2014