日本神経精神薬理学会, JSNP Excellent Presentation Award for AsCNP,The ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients
Indoleamine 2,3-dioxygenase 2 (IDO2) is an enzyme of the tryptophan-kynurenine pathway that is constitutively expressed in the brain. To provide insight into the physiological role of IDO2 in the brain, behavioral and neurochemical analyses in IDO...
Chronic orofacial pain (COP) is relieved by duloxetine (DLX) and frequently causes depressive symptoms. The aim of this study was to confirm effects of DLX on pain and depressive symptoms, and to associate with their effectiveness in pl...
British journal of pharmacology 180(18) 2393-2411 2023年4月
BACKGROUND AND PURPOSE: High salt (HS) intake has been associated with hypertension and cognitive impairment. It is well-known that angiotensin II (Ang II)-AT1 and prostaglandin E2 (PGE2)-EP1 systems are involved in hypertension and neurotoxicity....
We investigated the possibility of prostaglandin E2 (PGE2) as one of common molecules associated with vulnerability to neurodevelopmental disruptions induced by environmental factors. PGE2 levels in whole brain wer...
Quinolinic acid phosphoribosyltransferase (QPRT) metabolizes quinolinic acid (QA) to nicotinamide adenine nucleotide (NAD+) via kynurenine pathway. QA is a excitotoxic substance that activate N-methyl-D-aspertate (NMDA) receptors and NA...