The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the suprao...
Mizutani N   Ozaki N   Seino Y   Fukami A   Sakamoto E   Fukuyama T   Sugimura Y   Nagasaki H   Arima H   Oiso Y   
Experimental and Clinical Endocrinology & Diabetes 120(3) 139-44 2012年 [査読有り]
Familial neurohypophysial diabetes insipidus (FNDI) is caused by mutations in the gene locus of arginine vasopressin (AVP), an antidiuretic hormone. Although the carriers are normal at birth, polyuria and polydipsia appear several months or years ...
It is well known that glucoprivation induces the release of counterregulatory hormones such as glucagon, and that the response is attenuated when the stimuli are repeated. Glucoprivation also activates orexigenic neurons and induces hyperphagic re...
Julia Barsony   Yoshihisa Sugimura   Joseph G Verbalis   
The Journal of biological chemistry 286(12) 10864-75 2011年3月 [査読有り]
Our recent animal and human studies revealed that chronic hyponatremia is a previously unrecognized cause of osteoporosis that is associated with increased osteoclast numbers in a rat model of the human disease of the syndrome of inappropriate ant...