Journal of immunology (Baltimore, Md. : 1950) 212(7) 1221-1231 2024年4月
Pulmonary fibrosis is a fatal condition characterized by fibroblast and myofibroblast proliferation and collagen deposition. TGF-β plays a pivotal role in the development of pulmonary fibrosis. Therefore, modulation of TGF-β signaling is a promisi...
Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblast...
American journal of respiratory cell and molecular biology 68(2) 201-212 2022年10月 [査読有り]
Asthma is a chronic airway inflammatory disease characterized by airway hyperreactivity (AHR) and eosinophilic airway inflammation. Dendritic cells (DCs) are essential for the development of asthma via presenting allergens, causing Th2 skewing and...
Life Science Alliance 5(6) e202101230-e202101230 2022年6月
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment (TME). Most CAFs shape the TME toward an immunosuppressive milieu and attenuate the efficacy of immune checkpoint blockade (ICB) therapy. However, the det...
Mohammed A. Mansour   Toshinori Hyodo   Satoko Ito   Kenji Kurita   Toshio Kokuryo   Keisuke Uehara   Masato Nagino   Masahide Takahashi   Michinari Hamaguchi   Takeshi Senga   
FEBS JOURNAL 282(8) 1394-1405 2015年4月 [査読有り]
Special AT-rich sequence binding protein2 (SATB2) is an evolutionarily conserved transcription factor that has multiple roles in neuronal development, osteoblast differentiation, and craniofacial patterning. SATB2 binds to the nuclear matrix attac...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 459(2) 252-258 2015年4月 [査読有り]
CD109 is a glycosylphosphatidylinositol-anchored cell surface protein that is frequently detected in squamous cell carcinomas. CD109 is a negative regulator of TGF-beta 1 signaling in human keratinocytes, and the N-terminal fragment of CD109 secre...
Mohammed A. Mansour   Eri Asano   Toshinori Hyodo   K. A. Akter   Masahide Takahashi   Michinari Hamaguchi   Takeshi Senga   
EXPERIMENTAL CELL RESEARCH 332(1) 78-88 2015年3月 [査読有り]
Invadopodia are specialized actin-based microdomains of the plasma membrane that combine adhesive properties with matrix degrading activities. Proper functioning of the bone, immune, and vascular systems depend on these organelles, and their relev...
Spermatogonial stem cells (SSCs) are required for spermatogenesis. Earlier studies showed that glial cell line-derived neurotrophic factor (GDNF) was indispensable for SSC self-renewal by binding to the GFRA1/RET receptor. Mice with mutations in t...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458(4) 934-940 2015年3月 [査読有り]
The mammalian protein Girdin interacts with several key molecules such as actin, and it functions as a regulator of the cytoskeleton. Silencing of Girdin mRNA results in defective migration in a variety of cultured cells. Moreover, knockout of Gir...