European journal of pharmacology 931 175207-175207 2022年8月
Current antipsychotics used to treat schizophrenia have associated problems, including serious side effects and treatment resistance. We recently identified a significant association of schizophrenia with exonic copy number variations in the Rho G...
Acetylcholine is a neuromodulator critical for learning and memory. The cholinesterase inhibitor donepezil increases brain acetylcholine levels and improves Alzheimer's disease (AD)-associated learning disabilities. Acetylcholine activates striata...
The nucleus accumbens (NAc) plays critical roles in emotional behaviors, including aversive learning. Aversive stimuli such as an electric foot shock increase acetylcholine (ACh) in the NAc, and muscarinic signaling appears to increase neuronal ex...
Recently we have identified Arhgap10 gene mutations in Japanese schizophrenia patients by the genome-wide CNV analysis. ARHGAP10 negatively regulates Rho family small GTPases that play roles in the regulation of spine morphology. We also fo...
Glutamate induces Ca2+ influx in neurons through NMDA receptors (NMDARs) and activates Ca2+-dependent protein kinases, including CaMKII, which play critical roles in synaptic plasticity and learning. However, how these kinase...
Successful completion of daily activities relies on the ability to select the relevant features of the environment for memory and recall. Disruption to these processes can lead to various disorders, such as attention-deficit hyperactivity disorder...