Diphtheria toxin (DT) administration into trans genic mice that express the DT receptor (DTR) under control of specific promoters is often used for cell ablation studies in vivo. Because DTR is not expressed in mice, DT injection has been assumed ...
Japanese Journal of Cancer and Chemotherapy 44(2) 143-147 2017年2月 [査読有り]
Nedaplatin (NDP) is a platinum derivative anticancer drug. An NDP dose of 100 mg/m2 every 4 weeks is recommended in non-elderly Japanese patient because a higher dose may lead to myelosuppression, such as thrombocytopenia. In a pharmacokinetic ana...
Kubo, K.I   Deguchi, K   Nagai T   Ito, Y   Yoshida, K   Endo, T   Benner, S   Shan, W   Kitazawa, A   Aramaki, M   Ishii, K   Shin, M   Matsunaga, Y   Hayashi, K   Kakeyama, M   Tohyama, C   Tanaka, K.F   Tanaka, K   Takashima, S   Nakayama, M   Itoh, M   Hirata, Y   Antalffy, B   Armstrong, D.D   Yamada, K   Inoue, K   Nakajima, K   
Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies...
Successful completion of daily activities relies on the ability to select the relevant features of the environment for memory and recall. Disruption to these processes can lead to various disorders, such as attention-deficit hyperactivity disorder...