Objective The objective of this study was to estimate the humoral immune response evaluated by immunoglobulin G (IgG) against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD-IgG) following the th...
Nanaka Morita   Masato Hoshi   Hiroyuki Tezuka   Tatsuya Ando   Sayaka Yoshida   Fumiaki Sato   Hiroyuki Yokoi   Hiroyasu Ito   Kuniaki Saito   
ImmunoHorizons 7(5) 353-363 2023年5月
Sepsis is a systemic inflammatory disease caused by a bacterial infection that leads to severe mortality, especially in elderly patients, because of an excessive immune response and impaired regulatory functions. Antibiotic treatment is widely acc...
Tatusya Ando   Daisuke Ito   Kazuya Shiogama   Yasuhiro Sakai   Masato Abe   Takayasu Ideta   Ayumu Kanbe   Masahito Shimizu   Hiroyasu Ito   
Biochemical and Biophysical Research Communications 648 44-49 2023年3月 [査読有り]
A previous study revealed that treatment with the anticoagulant heparin attenuated concanavalin A (ConA)-induced liver injury. The administration of spermidine (SPD) increased urokinase-type plasminogen activator (uPA) levels in the serum. uPA is ...
INTERNATIONAL JOURNAL OF HEMATOLOGY 102(3) 327-334 2015年9月
Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step in the metabolism of tryptophan along the kynurenine pathway. In tumors, increased IDO activity inhibits proliferation and induces apoptosis of T cells and natural killer cells. We...
Saori Tada   Tsuneo Watanabe   Chigusa Suzuki   Yuzuru Nohisa   Koichi Shinoda   Nobuyuki Furuta   Hiroyasu Ito   Yoko Okumura   En Shu   Mariko Seishima   
JOURNAL OF ULTRASOUND IN MEDICINE 34(8) 1485-1488 2015年8月
Subcutaneous sarcoidosis occurs infrequently among cases of cutaneous sarcoidosis. To our knowledge, few studies have described the sonographic characteristics of subcutaneous sarcoidosis. Here we report the sonographic characteristics of 3 cases ...
Indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades the essential amino acid l-tryptophan along the kynurenine pathway, exerts immunomodulatory effects in a number of diseases. IDO expression is increased in tumor tissue and in draining lym...
DIGESTIVE DISEASES AND SCIENCES 60(6) 1699-1706 2015年6月
Background and Aim The liver has a high capacity of its regeneration. Most hepatic cells are quiescent unless otherwise stimulated such as their injury or ablation. A previous study suggest that pre-activated hepatic cells have a positive effect o...
ULTRASOUND IN MEDICINE AND BIOLOGY 41(6) 1779-1783 2015年6月
The aim of this study was to quantitatively assess the echo intensity of the supraspinatus muscle and compare magnetic resonance imaging and ultrasound findings for 27 patients (12 women, 15 men, 65.8 +/- 11.5 y). Tear size and fatty infiltration ...