研究者氏名	坪井良樹
	ツボイヨシキ
URL
所属	藤田医科大学
部署	医科学　医検　予防医科学分野研究推進ﾕﾆｯﾄ
職名	助教
学位	博士（医療科学）
科研費研究者番号	60908466
ORCID ID	0000-0001-8145-3949
J-Global ID	202101006497253995

研究キーワード

エピジェネティクス ,DNAメチル化 ,分子疫学

研究分野

ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない /

学歴

2020年4月

2023年3月

藤田医科大学保健学研究科

2016年4月

2018年3月

藤田保健衛生大学保健学研究科

2012年4月

2016年3月

藤田保健衛生大学医療科学部臨床検査学科

受賞

2021年12月

第80回日本公衆衛生学会総会, 優秀演題賞

論文

<4 5 678 >

Primary prophylaxis of febrile neutropenia with pegfilgrastim in small-cell lung cancer patients receiving amrubicin as second-line therapy

Sato, Y. Iihara, H. Kinomura, M. Hirose, C. Fujii, H. Endo, J. Yanase, K. Kaito, D. Sasaki, Y. Gomyo, T. Sakai, C. Iwai, M. Tsuboi, Y. Ishihara, T. Kobayashi, R. Ohno, Y. Suzuki, A.

Anticancer Research 41(3) 1615-1620 2021年

BACKGROUND/AIM: We evaluated the efficacy of primary prophylaxis with pegfilgrastim (PEG) for febrile neutropenia (FN) in small cell lung cancer (SCLC) patients receiving amrubicin (AMR). PATIENTS AND METHODS: A retrospective cohort study was cond...

Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels

Fujii, R. Yamada, H. Munetsuna, E. Yamazaki, M. Mizuno, G. Ando, Y. Maeda, K. Tsuboi, Y. Ohashi, K. Ishikawa, H. Hagiwara, C. Wakai, K. Hashimoto, S. Hamajima, N. Suzuki, K.

Nutrition 81 2021年

Objectives: A diet rich in fish and ω-3 polyunsaturated fatty acids (PUFAs) has been thought to reduce the risk for cardiovascular disease (CVD). The beneficial effects of fish oil and ω-3 PUFA on CVD can be mediated by epigenetic status of the ge...

Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population

Maeda, K. Yamada, H. Munetsuna, E. Fujii, R. Yamazaki, M. Ando, Y. Mizuno, G. Ishikawa, H. Ohashi, K. Tsuboi, Y. Hashimoto, S. Hamajima, N. Suzuki, K.

PLoS ONE 15(7) 2020年

Thioredoxin-interacting protein (TXNIP) inhibits the activity of thioredoxin (TXN), leading to increased oxidative stress. Expression of the TXNIP gene is regulated by DNA methylation. However, no study has reported the influence of lifestyle fact...

Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population

Fujii, R. Yamada, H. Munetsuna, E. Yamazaki, M. Ando, Y. Mizuno, G. Tsuboi, Y. Ohashi, K. Ishikawa, H. Hagiwara, C. Maeda, K. Hashimoto, S. Suzuki, K.

American Journal of Clinical Nutrition 110(5) 1213-1219 2019年

BACKGROUND: Higher intake of fruits and vegetables is associated with reduced risk of specific types of cancer and of cardiovascular disease (CVD), but the protective role of the vitamins contained in fruits and vegetables on CVD is controversial....

Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: The Yakumo study

Kondo, M. Yamada, H. Munetsuna, E. Yamazaki, M. Hatta, T. Iwahara, A. Ohashi, K. Ishikawa, H. Tsuboi, Y. Inoue, T. Fujii, R. Suzuki, K.

Archives of Gerontology and Geriatrics 82 155-160 2019年

Objectives: MicroRNAs (miRNAs) dysregulate gene expression by binding to target messenger RNAs, and play an important role in the pathogenesis of various diseases, including cancers, cardiovascular diseases and diabetes. Circulating miRNAs have in...