Yoko Ozawa M.D., Ph.D. works as a Chief of the Medical Retina Division (Age-related macular disease; AMD division) and a Vitreoretinal Surgeon, as well as a Lab Chief of the Laboratory of Retinal Cell Biology (RCB lab). Her recent research interest is the aging and neuroprotection of the retina, and its association with oxidative stress and inflammation. One of her missions is to find a neuroprotective treatment for the retinal diseases, such as AMD, diabetic retinopathy, and retinitis pigmentosa. During her training of the vitreoretinal surgery, she has become aware that simple surgical therapies do not always rescue the patients’ retina, and the additional approaches may be required for further improvement of the retinal conditions. Therefore, she joined a basic research lab, the Department of Physiology, Keio University School of Medicine, Prof. Hideyuki Okano’s Lab, for mastering neurobiology of the retina, including development and regeneration. After taking the Ph.D., she returned to Department of Ophthalmology, and started her research for learning the pathophysiology of the retinal diseases and exploring new therapeutic approaches.
研究キーワード
神経保護、老化、酸化ストレス、炎症
研究分野
ライフサイエンス / 眼科学 /
学歴
1986年4月
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1992年3月
慶應義塾大学 医学部
受賞
2016年
Global Ophthalmology Awards Program Research Award
Mariko Sasaki Kenya Yuki Akiko Hanyuda Kazumasa Yamagishi Kaoru Motomura Toshihide Kurihara Yohei Tomita Kiwako Mori Nobuhiro Ozawa Yoko Ozawa Norie Sawada Kazuno Negishi Kazuo Tsubota Shoichiro Tsugane Hiroyasu Iso
Scientific Reports 13(1) 2023年8月
Abstract
Residents of Chikusei City, aged 40–74 years, underwent systemic and ophthalmological screening, and participants with diabetes were included in this analysis. Dietary intake was assessed using a food frequency questionnaire and calculat...
PURPOSE: To determine the associations between fatty acid intakes and the prevalence of age-related macular degeneration (AMD) under a population-based cross-sectional study. METHODS: Residents of Chikusei City aged ≥40 years underwent systemic an...
Yoko Ozawa Eriko Toda Kohei Homma Hideto Osada Norihiro Nagai Kazuo Tsubota Hideyuki Okano
Cells 11(9) 2022年4月
Retinitis pigmentosa (RP) is a hereditary blinding disease characterized by gradual photoreceptor death, which lacks a definitive treatment. Here, we demonstrated the effect of 4-phenylbutyric acid (PBA), a chemical chaperon that can suppress endo...
<title>Abstract</title>This population-based cross-sectional study was performed to determine the mean corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX), and their associations with myopia in Japanese ad...
Hirohiko Kawashima Yoko Ozawa Eriko Toda Kohei Homma Hideto Osada Toshio Narimatsu Norihiro Nagai Kazuo Tsubota
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34(4) 5016-5026 2020年4月
Progression of blinding diseases, such as age-related macular degeneration, is accelerated by light exposure. However, no particular intervention is applied to the photostress. Here, we report neuroprotective effects of the adenosine monophosphate...
お知らせ・マニュアル
医学部