研究者氏名	山崎淳太郎
	ヤマサキジユンタロウ
URL
所属	藤田医科大学
部署	がん医療研究センター　遺伝子制御研究部門
職名	博士研究員
学位	博士（医学）(慶應義塾大学)
科研費研究者番号	10963580
J-Global ID	202201011942377650

研究キーワード

胃癌 ,癌幹細胞 ,治療抵抗性 ,腫瘍生物学

研究分野

ライフサイエンス / 腫瘍生物学 /

経歴

2023年4月

現在

藤田医科大学がん医療研究センター博士研究員

2022年4月

2023年3月

慶應義塾大学特任助教

学歴

2018年4月

2022年3月

慶應義塾大学大学院医学研究科医学研究系専攻

2016年4月

2018年3月

慶應義塾大学大学院医学研究科医科学専攻

2012年4月

2016年3月

慶應義塾大学薬学部薬科学科

受賞

2022年10月

日本癌学会, JCA若手研究者ポスター賞

論文

12 3 >

RAC1-mediated Integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination.

Jun Zhang Lingfeng Fu Huaitao Wang Atsuko Yonemura Takashi Semba Noriko Yasuda-Yoshihara Akiho Nishimura Takuya Tajiri Yilin Tong Tadahito Yasuda Tomoyuki Uchihara Masaya Yamazaki Yuya Okamoto Juntaro Yamasaki Osamu Nagano Hideo Baba Takatsugu Ishimoto

Cancer letters 216901-216901 2024年4月 [査読有り]

Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer that is prone to peritoneal dissemination, with poor patient prognosis. Although intercellular adhesion loss between cancer cells is a major characteristic of DGCs, the mechanism und...

Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment.

Atsuko Yonemura Takashi Semba Jun Zhang Yibo Fan Noriko Yasuda-Yoshihara Huaitao Wang Tomoyuki Uchihara Tadahito Yasuda Akiho Nishimura Lingfeng Fu Xichen Hu Feng Wei Fumimasa Kitamura Takahiko Akiyama Kohei Yamashita Kojiro Eto Shiro Iwagami Masaaki Iwatsuki Yuji Miyamoto Keisuke Matsusaki Juntaro Yamasaki Osamu Nagano Hideyuki Saya Shumei Song Patrick Tan Hideo Baba Jaffer A Ajani Takatsugu Ishimoto

Cell reports 43(1) 113613-113613 2024年1月 [査読有り]

Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic profiling and a com...

Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer.

Fumimasa Kitamura Takashi Semba Noriko Yasuda-Yoshihara Kosuke Yamada Akiho Nishimura Juntaro Yamasaki Osamu Nagano Tadahito Yasuda Atsuko Yonemura Yilin Tong Huaitao Wang Takahiko Akiyama Kazuki Matsumura Norio Uemura Rumi Itoyama Luke Bu Lingfeng Fu Xichen Hu Feng Wei Kosuke Mima Katsunori Imai Hiromitsu Hayashi Yo-Ichi Yamashita Yuji Miyamoto Hideo Baba Takatsugu Ishimoto

JCI insight 8(20) 2023年9月 [査読有り]

Glycolysis is highly enhanced in Pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment (TME). However, little is known about how such glucose competition alters m...

A novel tdTomato transgenic mouse model to visualize FAP-positive cancer-associated fibroblasts.

Wei F Uchihara T Yonemura A Yasuda-Yoshihara N Yasuda T Semba T Fukuda M Akiyama T Kitamura F Bu L Hu X Fu L Zhang J Kariya R Yamasaki J Aihara K Yamashita K Nagano O Okada S Baba H Ishimoto T

The FEBS journal 290(10) 2604-2615 2022年12月 [査読有り]

Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.

Akiyama T Yasuda T Uchihara T Yasuda-Yoshihara N Tan BJY Yonemura A Semba T Yamasaki J Komohara Y Ohnishi K Wei F Fu L Zhang J Kitamura F Yamashita K Eto K Iwagami S Tsukamoto H Umemoto T Masuda M Nagano O Satou Y Saya H Tan P Baba H Ishimoto T

Cancer research 83(5) 753-770 2022年12月 [査読有り]