RNA-binding motif 10 (Rbm10) is an RNA-binding protein that regulates alternative splicing, but its role in inflammation is not well defined. Here, we show that Rbm10 controls appropriate splicing of DNA (cytosine-5)-methyltransferase 3b (Dnmt3b),...
KDEL receptors are responsible for retrotransporting endoplasmic reticulum (ER) chaperones from the Golgi complex to the ER. Here we describe a role for KDEL receptor 1 (KDELR1) that involves the regulation of integrated stress responses (ISR) in ...
Kokichi Katsunuma Koji Yoshinaga Yuta Ohira Runa Eta Takanori Sato Takayuki Horii Takao Tanaka Mineo Takei Koichi Seto
Molecular immunology 64(1) 218-27 2015年3月
Macrophages are a major component of the innate immune system, and the cytokines they secrete are involved in antitumor responses. Z-100 is obtained from hot-water extract of human-type Mycobacterium tuberculosis strain Aoyama B and activates the ...
Daisuke Kamimura Toru Atsumi Andrea Stofkova Naoki Nishikawa Takuto Ohki Hironao Suzuki Kokichi Katsunuma Jing-Jing Jiang Hidenori Bando Jie Meng Lavannya Sabharwal Hideki Ogura Toshio Hirano Yasunobu Arima Masaaki Murakami
Frontiers in immunology 6 638-638 2015年
The survival of naïve T cells is believed to require signals from TCR-pMHC interactions and cytokines such as IL-7. In contrast, signals that negatively impact naïve T cell survival are less understood. We conducted a forward genetic screening of ...
Takayuki Horii Koji Yoshinaga Nobuyoshi Kobayashi Koichi Seto Yuki Orikawa Masahiro Okamoto Runa Eta Yuta Ohira Kokichi Katsunuma Yuko Hori Takao Tanaka Mineo Takei
Lymphatic metastasis is common in advanced-stage carcinoma and is associated with a poor prognosis. However, few effective treatments to inhibit it are available. Z-100 is an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B t...
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