Kazuhiko Okamura Johannes M. Dijkstra Kentaro Tsukamoto Unni Grimholt Geert F. Wiegertjes Akiko Kondow Hisateru Yamaguchi Keiichiro Hashimoto
Proceedings of the National Academy of Sciences 118(51) 2021年12月
Two classes of major histocompatibility complex (MHC) molecules, MHC class I and class II, play important roles in our immune system, presenting antigens to functionally distinct T lymphocyte populations. However, the origin of this essential MHC ...
Grimholt, U. Tsukamoto, K. Azuma, T. Leong, J. Koop, B.F. Dijkstra, J.M.
BMC Evolutionary Biology 15(1) 309 2015年3月 [査読有り]
Background
MHC class I (MHCI) molecules are the key presenters of peptides generated through the intracellular pathway to CD8-positive T-cells. In fish, MHCI genes were first identified in the early 1990's, but we still know little about their fun...
Biochemical and Biophysical Research Communications 443(2) 422-427 2014年1月 [査読有り]
The major histocompatibility complex (MHC) class I-related molecule, MR1, is highly conserved in mammals and can present bacteria-derived vitamin B metabolites to mucosal-associated invariant T (MAIT) cells, possibly having important defense funct...
Tsukamoto, K. Deakin, J.E. Graves, J.A.M. Hashimoto, K.
Immunogenetics 65(2) 115-124 2013年2月 [査読有り]
The major histocompatibility complex (MHC) class I-related gene, MR1, is a non-classical MHC class IA gene and is encoded outside the MHC region. The MR1 is responsible for activation of mucosal-associated invariant T (MAIT) cells expressing semi-...
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