高橋雅英

研究者氏名	高橋雅英
	タカハシマサヒデ
URL
所属	藤田医科大学
部署	国際再生医療センター
職名	センター長、特命教授
学位	医学博士(名古屋大学)
その他の所属	研究統括監理部
J-Global ID	200901036145308243

研究キーワード

神経新生 ,血管新生 ,レセプター型チロシンキナーゼ ,神経栄養因子 ,腸管神経系 ,神経分化 ,癌の浸潤・転移 ,細胞増殖 ,癌

研究分野

ライフサイエンス / 実験病理学 /

経歴

2020年4月

現在

藤田医科大学国際再生医療センターセンター長、特命教授

2020年4月

現在

藤田医科大学研究統括監理部特命教授統括学術プログラムディレクター

2017年4月

2020年3月

名古屋大学役員等医学系研究科・教授

2013年4月

2020年3月

名古屋大学大学院医学系研究科附属神経疾患・腫瘍分子医学研究センター先端応用医学部門教授

2004年10月

2013年3月

名古屋大学大学院医学系研究科附属神経疾患・腫瘍分子医学研究センター教授

学歴

1983年3月

名古屋大学医学研究科病理学

1979年3月

名古屋大学医学部医学

受賞

12 >

2020年11月

日本国政府, 紫綬褒章

2020年2月

高松宮妃癌研究基金, 高松宮妃癌研究基金学術賞

2019年11月

日本医師会, 日本医師会医学賞

2010年5月

中日新聞社, 中日文化賞

2006年3月

読売新聞社, 読売東海医学賞

論文

12 3 4 5 >

CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling.

Hyogo Naoi Yuzo Suzuki Asuka Miyagi Ryo Horiguchi Yuya Aono Yusuke Inoue Hideki Yasui Hironao Hozumi Masato Karayama Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Naoki Inui Shinji Mii Masatoshi Ichihara Masahide Takahashi Takafumi Suda

Journal of immunology (Baltimore, Md. : 1950) 212(7) 1221-1231 2024年4月

Pulmonary fibrosis is a fatal condition characterized by fibroblast and myofibroblast proliferation and collagen deposition. TGF-β plays a pivotal role in the development of pulmonary fibrosis. Therefore, modulation of TGF-β signaling is a promisi...

Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.

Ryota Ando Yukihiro Shiraki Yuki Miyai Hiroki Shimizu Kazuhiro Furuhashi Shun Minatoguchi Katsuhiro Kato Akira Kato Tadashi Iida Yasuyuki Mizutani Kisuke Ito Naoya Asai Shinji Mii Nobutoshi Esaki Masahide Takahashi Atsushi Enomoto

The Journal of pathology 2023年10月

Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblast...

CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation.

Yuya Aono Yuzo Suzuki Ryo Horiguchi Yusuke Inoue Masato Karayama Hironao Hozumi Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Shinji Mii Masahide Takahashi Takafumi Suda

American journal of respiratory cell and molecular biology 68(2) 201-212 2022年10月 [査読有り]

Asthma is a chronic airway inflammatory disease characterized by airway hyperreactivity (AHR) and eosinophilic airway inflammation. Dendritic cells (DCs) are essential for the development of asthma via presenting allergens, causing Th2 skewing and...

骨肉腫におけるMeflin陽性細胞を標的とした抗体薬物複合体の研究開発(An Effective Therapy that Antibody-Drug Conjugates Targeting Meflin(+) Cells for Osteosarcoma)

迫田朋佳江崎寛季安藤良太宮井雄基飯田忠松山誠白木之浩三井伸二西田佳弘高橋雅英榎本篤

日本癌学会総会記事 81回 E-2021 2022年9月

Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade

Yuki Miyai Daisuke Sugiyama Tetsunari Hase Naoya Asai Tetsuro Taki Kazuki Nishida Takayuki Fukui Toyofumi Fengshi Chen-Yoshikawa Hiroki Kobayashi Shinji Mii Yukihiro Shiraki Yoshinori Hasegawa Hiroyoshi Nishikawa Yuichi Ando Masahide Takahashi Atsushi Enomoto

Life Science Alliance 5(6) e202101230-e202101230 2022年6月

Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment (TME). Most CAFs shape the TME toward an immunosuppressive milieu and attenuate the efficacy of immune checkpoint blockade (ICB) therapy. However, the det...

MISC

12 3 4 5 >

Dissection of the function of CD109 in lung adenocarcinoma

Tetsuro Taki Shinji Mii Yukihiro Shiraki Atsushi Enomoto Masahide Takahashi

CANCER SCIENCE 109 1407-1407 2018年12月

Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis

Yoshinori Yasuda Shintaro Iwama Atsushi Kiyota Hisakazu Izumida Kohtaro Nakashima Naoko Iwata Yoshihiro Ito Yoshiaki Morishita Motomitsu Goto Hidetaka Suga Ryoichi Banno Atsushi Enomoto Masahide Takahashi Hiroshi Arima Yoshihisa Sugimura

Journal of Pathology 244(4) 469-478 2018年4月 [査読有り]

Autoimmune hypophysitis (AH) is thought to be an autoimmune disease characterized by lymphocytic infiltration of the pituitary gland. Among AH pathologies, lymphocytic infundibulo-neurohypophysitis (LINH) involves infiltration of the neurohypophys...

Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note

Kaori Ushida Naoya Asai Kozo Uchiyama Atsushi Enomoto Masahide Takahashi

Pathology International 68(4) 241-245 2018年4月 [査読有り]

Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap-freezing followed by microt...

Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11

Tomoki Maegawa Yuki Miyasaka Misato Kobayashi Naru Babaya Hiroshi Ikegami Fumihiko Horio Masahide Takahashi Tamio Ohno

Mammalian Genome 29(3-4) 273-280 2018年4月 [査読有り]

Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported
however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the ...

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.

Liang Weng Yi-Peng Han Atsushi Enomoto Yasuyuki Kitaura Shushi Nagamori Yoshikatsu Kanai Naoya Asai Jian An Maki Takagishi Masato Asai Shinji Mii Takashi Masuko Yoshiharu Shimomura Masahide Takahashi

PLoS biology 16(3) e2005090 2018年3月

Amino acid signaling mediated by the activation of mechanistic target of rapamycin complex 1 (mTORC1) is fundamental to cell growth and metabolism. However, how cells negatively regulate amino acid signaling remains largely unknown. Here, we show ...