研究者氏名	山崎未来

URL
所属	藤田医科大学
部署	医学部医学科衛生学
職名	講師
学位	博士(医療科学)
J-Global ID	201901005807798674

研究分野

ライフサイエンス / 栄養学、健康科学 /
ライフサイエンス / 代謝、内分泌学 /
ライフサイエンス / 分子生物学 /

経歴

2023年10月

現在

藤田医科大学医学部医学科衛生学講師

2023年4月

2023年9月

香川県立保健医療大学保健医療学部臨床検査学科講師

2019年4月

2023年3月

香川県立保健医療大学保健医療学部臨床検査学科助教

2017年4月

2019年3月

藤田医科大学大学院保健学研究科日本学術振興会特別研究員DC2

論文

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Association between DNA methylation levels of thioredoxin-interacting protein (TXNIP) and changes in glycemic traits: a longitudinal population-based study.

Keisuke Maeda Ryosuke Fujii Hiroya Yamada Eiji Munetsuna Mirai Yamazaki Yoshitaka Ando Genki Mizuno Hiroaki Ishikawa Koji Ohashi Yoshiki Tsuboi Yuji Hattori Yuya Ishihara Nobuyuki Hamajima Shuji Hashimoto Koji Suzuki

Endocrine journal 2024年3月

Thioredoxin-interacting protein (TXNIP) plays an important role in glucose metabolism, and its expression is regulated by DNA methylation (DNAm). Although the association between TXNIP DNAm and type 2 diabetes mellitus has been demonstrated in stu...

Impact of maternal fructose intake on liver stem/progenitor cells in offspring: Insights into developmental origins of health and disease.

Yoshitaka Ando Eiji Munetsuna Hiroya Yamada Miyuki Ikeya Atsushi Teshigawara Itsuki Kageyama Yuki Nouchi Takuya Wakasugi Mirai Yamazaki Genki Mizuno Yoshiki Tsuboi Hiroaki Ishikawa Nobutaka Ohgami Koji Suzuki Koji Ohashi

Life sciences 336 122315-122315 2024年1月

AIMS: The developmental origin of health and disease (DOHaD) theory postulates that poor nutrition during fetal life increases the risk of disease later in life. Excessive fructose intake has been associated with obesity, diabetes, and nonalcoholi...

Low mitochondrial DNA copy number in peripheral blood mononuclear cells is associated with future mortality risk: a long-term follow-up study from Japan.

Genki Mizuno Hiroya Yamada Yoshiki Tsuboi Eiji Munetsuna Mirai Yamazaki Yoshitaka Ando Itsuki Kageyama Yuki Nouchi Atsushi Teshigawara Yuji Hattori Ryosuke Fujii Hiroaki Ishikawa Shuji Hashimoto Koji Ohashi Nobuyuki Hamajima Koji Suzuki

The journal of nutrition, health & aging 28(1) 100013-100013 2024年1月

OBJECTIVES: The mitochondrial DNA (mtDNA) is unique and circular with multiple copies of the genome. The lower mtDNA copy number (mtDNA-CN) in leukocytes is associated with the risk of all-cause mortality. However, its long-term association is unk...

Serum carotenoid levels are positively associated with DNA methylation of thioredoxin-interacting protein.

Keisuke Maeda Hiroya Yamada Eiji Munetsuna Ryosuke Fujii Mirai Yamazaki Yoshitaka Ando Genki Mizuno Yoshiki Tsuboi Hiroaki Ishikawa Koji Ohashi Shuji Hashimoto Nobuyuki Hamajima Koji Suzuki

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2023年9月 [査読有り]

Background: Carotenoids have been reported to exert protective effects against age-related diseases via changes in DNA methylation. Although lower thioredoxin-interacting protein (TXNIP) DNA methylation is associated with age-related diseases, onl...

Integration of methylation quantitative trait loci (mQTL) on dietary intake on DNA methylation levels: an example of n-3 PUFA and ABCA1 gene.

Ryosuke Fujii Yoshitaka Ando Hiroya Yamada Yoshiki Tsuboi Eiji Munetsuna Mirai Yamazaki Genki Mizuno Keisuke Maeda Koji Ohashi Hiroaki Ishikawa Mami Watanabe Nahomi Imaeda Chiho Goto Kenji Wakai Shuji Hashimoto Koji Suzuki

European journal of clinical nutrition 77(9) 881-887 2023年9月 [査読有り]

BACKGROUND: Epigenetic studies have reported relationships between dietary nutrient intake and methylation levels. However, genetic variants that may affect DNA methylation (DNAm) pattern, called methylation quantitative loci (mQTL), are usually o...