Toshiharu Nagatsu Akira Nakashima Hirohisa Watanabe Shosuke Ito Kazumasa Wakamatsu Fabio A. Zucca Luigi Zecca Moussa Youdim Maximilian Wulf Peter Riederer Johannes M. Dijkstra
Journal of Neural Transmission 2023年3月
Abstract
The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in the human brain. During the progression of Parkinson’s dis...
<title>Abstract</title>
Neopterin (NP), biopterin (BP) and monapterin (MP) exist in saliva. The physiological role of salivary NP as well as the pathophysiological role of increased NP in the immune-activated state has been unclear. Saliva is a c...
Akira Nakashima Hisateru Yamaguchi Mii Kondo Takahiro Furumura Yu Kodani Yoko S Kaneko Miho Kawata Hiroshi Nagasaki Toshiharu Nagatsu Akira Ota
Journal of neural transmission (Vienna, Austria : 1996) 2020年8月 [査読有り]
5'-Nucleotidase domain-containing protein 2 (NT5DC2) has been revealed by genome-wide association studies (GWAS) as a gene implicated in neuropsychiatric disorders related to the abnormality of dopamine (DA) activity in the brain. Based on its ami...
JOURNAL OF NEURAL TRANSMISSION 123(11) 1255-1278 2016年11月
Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs),...
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医学部