Atsushi Nambu Satomi Chiken Hiromi Sano Nobuhiko Hatanaka José A Obeso
Movement disorders : official journal of the Movement Disorder Society 38(12) 2145-2150 2023年12月
Schematic illustration of cortically induced dynamic activity changes of the output nuclei of the basal ganglia (the internal segment of the globus pallidus, GPi and the substantia nigra pars reticulata, SNr) in the healthy and diseased states. Th...
Cell reports. Medicine 101208-101208 2023年9月 [査読有り]
Dyskinesia is involuntary movement caused by long-term medication with dopamine-related agents: the dopamine agonist 3,4-dihydroxy-L-phenylalanine (L-DOPA) to treat Parkinson's disease (L-DOPA-induced dyskinesia [LID]) or dopamine antagonists to t...
Frontiers in aging neuroscience 15 1221341-1221341 2023年
Zonisamide (ZNS; 1,2-benzisoxazole-3-methanesulfonamide) was initially developed and is commonly used as an anticonvulsant drug. However, it has also shown its beneficial effects on Parkinson's disease (PD), a progressive neurodegenerative disorde...
Dysfunctional dopamine signaling is implicated in various neuropsychological disorders. Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium spiny neuron (MSN) excitability and firing rates in the nucleus accumbens (...
H. Takebayashi M. Horie K. K. Mekada H. Sano Y. Kikkawa S. Chiken T. Someya K. Saito M. I. Hossain M. Nameta K. Abe K. Sakimura K. Ono A. Nambu A. Yoshiki
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