研究者氏名	戸邊隆夫
	ﾄﾍﾞﾀｶｵ
URL
所属	藤田医科大学
部署	医学部　薬物治療情報学
職名	助教
J-Global ID	202301001265527730

研究分野

ライフサイエンス / 医療薬学 / 骨粗鬆症

論文

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Influence of Brain Metastasis on Analgesia-Related Outcomes in Patients with Lung and Breast Cancers Treated with Naldemedine: A Propensity Score-Matched Analysis.

Aya Hanamoto Takenao Koseki Ayaka Utsunomiya Takuma Ishihara Takao Tobe Masashi Kondo Yuko Kijima Hiroshi Matsuoka Tomohiro Mizuno Takahiro Hayashi Shigeki Yamada

Journal of clinical medicine 12(22) 2023年11月

Naldemedine is structurally designed to prevent passage across the blood-brain barrier (BBB), resulting in the attenuation of opioid-induced constipation without interfering with the analgesic effects of opioids. However, the influence of brain me...

Hospital-Wide Surveillance of Fracture Risk Assessment by Both FRAX and Medication Patterns in Acute Care Hospital.

Takao Tobe Misaki Kubo Takahiro Toda Mitsuhiro Morita Mika Watanabe Shigeki Yamada Atsushi Suzuki Takahiro Hayashi

Biological & pharmaceutical bulletin 45(7) 881-887 2022年7月

To identify patients at a high risk for primary and secondary osteoporotic fractures using fracture risk assessments performed using the current method and the proposed method, in an acute care hospital and to identify departments where high-risk ...

Indirubin 3'-Oxime Inhibits Migration, Invasion, and Metastasis InVivo in Mice Bearing Spontaneously Occurring Pancreatic Cancer via Blocking the RAF/ERK, AKT, and SAPK/JNK Pathways.

Yoshimi Ichimaru Makoto Sano Ichie Kajiwara Takao Tobe Hiroki Yoshioka Kazuhiko Hayashi Hideaki Ijichi Shinichi Miyairi

Translational oncology 12(12) 1574-1582 2019年12月

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high invasive and metastatic potential. We generated a spontaneous PDAC mouse model and examined the therapeutic potential of indirubin 3'-oxime (Indox) against PDAC ...

Selenium uptake through cystine transporter mediated by glutathione conjugation.

Takao Tobe Koji Ueda Akira Aoki Yoshinori Okamoto Nakao Kojima Hideto Jinno

The Journal of toxicological sciences 42(1) 85-91 2017年

Selenium (Se) is an essential trace element and is regarded as a protective agent against cancer. In particular, antioxidant effects of selenoenzymes contribute to cancer prevention. Se can also produce reactive oxygen species and, thereby, exert ...

Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.

Takao Tobe Koji Ueda Motozumi Ando Yoshinori Okamoto Nakao Kojima

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20(4) 687-94 2015年6月

Selenium (Se) is an essential antioxidative micronutrient but can exert cancer-selective cytotoxicity if the nutritional levels are too high. Selenodiglutathione (GSSeSG) is a primary Se metabolite conjugated with two glutathione (GSH) moieties. G...