研究者氏名	坪井良樹
	ツボイヨシキ
URL
所属	藤田医科大学
部署	医科学　医検　予防医科学分野研究推進ﾕﾆｯﾄ
職名	助教
学位	博士（医療科学）
科研費研究者番号	60908466
ORCID ID	0000-0001-8145-3949
J-Global ID	202101006497253995

研究キーワード

エピジェネティクス ,DNAメチル化 ,分子疫学

研究分野

ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない /

学歴

2020年4月

2023年3月

藤田医科大学保健学研究科

2016年4月

2018年3月

藤田保健衛生大学保健学研究科

2012年4月

2016年3月

藤田保健衛生大学医療科学部臨床検査学科

受賞

2021年12月

第80回日本公衆衛生学会総会, 優秀演題賞

論文

12 3 4 5 >

Association between DNA methylation levels of thioredoxin-interacting protein (TXNIP) and changes in glycemic traits: a longitudinal population-based study.

Keisuke Maeda Ryosuke Fujii Hiroya Yamada Eiji Munetsuna Mirai Yamazaki Yoshitaka Ando Genki Mizuno Hiroaki Ishikawa Koji Ohashi Yoshiki Tsuboi Yuji Hattori Yuya Ishihara Nobuyuki Hamajima Shuji Hashimoto Koji Suzuki

Endocrine journal 2024年3月

Thioredoxin-interacting protein (TXNIP) plays an important role in glucose metabolism, and its expression is regulated by DNA methylation (DNAm). Although the association between TXNIP DNAm and type 2 diabetes mellitus has been demonstrated in stu...

Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit.

Eirin Sakaguchi Hiroyuki Naruse Yuya Ishihara Hidekazu Hattori Akira Yamada Hideki Kawai Takashi Muramatsu Yoshiki Tsuboi Ryosuke Fujii Koji Suzuki Junnichi Ishii Kuniaki Saito Masayoshi Sarai Masanobu Yanase Yukio Ozaki Hideo Izawa

Scientific reports 14(1) 75-75 2024年1月

The renal angina index (RAI) is a validated scoring tool for predicting acute kidney injury (AKI). We investigated the efficacy of the RAI in 2436 heterogeneous patients (mean age, 70 years) treated in cardiac intensive care units (CICUs). The RAI...

Impact of maternal fructose intake on liver stem/progenitor cells in offspring: Insights into developmental origins of health and disease.

Yoshitaka Ando Eiji Munetsuna Hiroya Yamada Miyuki Ikeya Atsushi Teshigawara Itsuki Kageyama Yuki Nouchi Takuya Wakasugi Mirai Yamazaki Genki Mizuno Yoshiki Tsuboi Hiroaki Ishikawa Nobutaka Ohgami Koji Suzuki Koji Ohashi

Life sciences 336 122315-122315 2024年1月

AIMS: The developmental origin of health and disease (DOHaD) theory postulates that poor nutrition during fetal life increases the risk of disease later in life. Excessive fructose intake has been associated with obesity, diabetes, and nonalcoholi...

Low mitochondrial DNA copy number in peripheral blood mononuclear cells is associated with future mortality risk: a long-term follow-up study from Japan.

Genki Mizuno Hiroya Yamada Yoshiki Tsuboi Eiji Munetsuna Mirai Yamazaki Yoshitaka Ando Itsuki Kageyama Yuki Nouchi Atsushi Teshigawara Yuji Hattori Ryosuke Fujii Hiroaki Ishikawa Shuji Hashimoto Koji Ohashi Nobuyuki Hamajima Koji Suzuki

The journal of nutrition, health & aging 28(1) 100013-100013 2024年1月

OBJECTIVES: The mitochondrial DNA (mtDNA) is unique and circular with multiple copies of the genome. The lower mtDNA copy number (mtDNA-CN) in leukocytes is associated with the risk of all-cause mortality. However, its long-term association is unk...

Serum carotenoid levels are positively associated with DNA methylation of thioredoxin-interacting protein.

Keisuke Maeda Hiroya Yamada Eiji Munetsuna Ryosuke Fujii Mirai Yamazaki Yoshitaka Ando Genki Mizuno Yoshiki Tsuboi Hiroaki Ishikawa Koji Ohashi Shuji Hashimoto Nobuyuki Hamajima Koji Suzuki

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2023年9月

Background: Carotenoids have been reported to exert protective effects against age-related diseases via changes in DNA methylation. Although lower thioredoxin-interacting protein (TXNIP) DNA methylation is associated with age-related diseases, onl...