研究者氏名	黒澤仁
	クロサワジン
URL	http://kaken.nii.ac.jp/d/r/10410739.ja.html
所属	藤田医科大学
部署	その他部局等
職名
学位	理学博士(名古屋大学)
J-Global ID	201401018482788607

研究キーワード

腫瘍学 ,抗体

研究分野

ライフサイエンス / 腫瘍診断、治療学 /

論文

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Development of anti-human CADM1 monoclonal antibodies as a potential therapy for adult T-cell leukemia/lymphoma.

Syahrul Chilmi Shingo Nakahata Yanuar Rahmat Fauzi Tomonaga Ichikawa Chikako Tani Mathurot Suwanruengsri Ryoji Yamaguchi Tadashi Matsuura Gene Kurosawa Kazuhiro Morishita

International journal of hematology 112(4) 496-503 2020年10月 [査読有り]

Adult T-cell leukemia/lymphoma (ATLL) is a highly invasive and refractory T-cell malignancy, with poor prognosis. We previously identified that cell adhesion molecule 1 (CADM1) is overexpressed consistently in ATLL cells, and that CADM1 expression...

Corrigendum to "Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphomaˮ [Biochem. Biophys. Res. Commun. 485 (1) 2017 144-151].

Shunsuke Shimosaki Shingo Nakahata Tomonaga Ichikawa Akira Kitanaka Takuro Kameda Tomonori Hidaka Yoko Kubuki Gene Kurosawa Lilin Zhang Yukio Sudo Kazuya Shimoda Kazuhiro Morishita

Biochemical and biophysical research communications 530(2) 486-486 2020年9月 [査読有り]

Radiolabeled Human Monoclonal Antibody 067-213 has the Potential for Noninvasive Quantification of CD73 Expression.

Hitomi Sudo Atsushi B Tsuji Aya Sugyo Gene Kurosawa Yoshikazu Kurosawa David Alexander Hiroyuki Tsuda Tsuneo Saga Tatsuya Higashi

International journal of molecular sciences 21(7) 2020年3月 [査読有り]

BACKGROUND: CD73 is an ectonucleotidase regulating extracellular adenosine concentration and plays an important role in adenosine-mediated immunosuppressive pathways. The efficacy of CD73-targeted therapy depends on the expression levels of CD73; ...

A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors.

Narumi Uno Tomohito Fujimoto Shinya Komoto Gene Kurosawa Masaaki Sawa Teruhiko Suzuki Yasuhiro Kazuki Mitsuo Oshimura

Cytotechnology 70(6) 1499-1508 2018年12月 [査読有り]

G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that interact with the β-arrestin family, particularly β-arrestin 1 (ARRB1). GPCRs interact with 33% of small molecule drugs. Ligand screening is promising for drug disco...

Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with 90Y-Labeled Fully Human Anti-CD147 Monoclonal Antibody 059-053 in a BxPC-3 Xenograft Mouse Model of Refractory Pancreatic Cancer.

Aya Sugyo Atsushi B Tsuji Hitomi Sudo Mitsuru Koizumi Yoshinori Ukai Gene Kurosawa Yoshikazu Kurosawa Tsuneo Saga Tatsuya Higashi

International journal of molecular sciences 19(10) 2018年9月 [査読有り]

The poor prognosis of pancreatic cancer requires the development of more effective therapy. CD147 expresses in pancreatic cancer with high incidence and has a crucial role in invasion and metastasis. We developed a fully human monoclonal antibody ...