Many people have a history of catching the flu several times during childhood but no additional flu in adulthood, even without vaccination. We analyzed the total repertoire of antibodies (Abs) against influenza A group 1 viruses induced in such a ...
JOURNAL OF VIROLOGY 85(21) 11048-11057 2011年11月 [査読有り]
Influenza A viruses are classified into 16 subtypes according to the serotypes of hemagglutinin (HA). It is generally thought that neutralizing antibodies (Abs) are not broadly cross-reactive among HA subtypes. We examined the repertoire of neutra...
Jun Okada   Nobuko Ohshima   Ritsuko Kubota-Koketsu   Yoshitaka Iba   Sayuri Ota   Wakana Takase   Tetsushi Yoshikawa   Toyokazu Ishikawa   Yoshizo Asano   Yoshinobu Okuno   Yoshikazu Kurosawa   
JOURNAL OF GENERAL VIROLOGY 92(Pt 2) 326-335 2011年2月 [査読有り]
Through extensive isolation of neutralizing mAbs against H3N2 influenza viruses representing the in vivo repertoire in a human donor, we examined the relationships between antigenic drift of influenza virus and protective antibodies generated in a...
Jun Okada   Nobuko Ohshima   Ritsuko Kubota-Koketsu   Sayuri Ota   Wakana Takase   Masachika Azuma   Yoshitaka Iba   Naoko Nakagawa   Tetsushi Yoshikawa   Youichi Nakajima   Toyokazu Ishikawa   Yoshizo Asano   Yoshinobu Okuno   Yoshikazu Kurosawa   
VIROLOGY 397(2) 322-330 2010年2月 [査読有り]
We tried to reveal the strain specificity of neutralizing mAbs against H3N2 influenza viruses in individuals. A large number of B lymphocytes of a pediatrician were collected by apheresis and two Ab libraries were constructed at 2004 and 2007 by u...
HMN-176 ((E)-4-([2-N-[4-methoxybenzenesulfonyl]amino]stilbazole]1-oxide) is an active metabolite of HMN-214 ((E)-4-{2-[2-(N-acetyl-N-[4-methoxybenzenesulfonyl]amino)stilbazole]1- -oxide), which has a potent antitumor activity in mouse xenograft mo...