大島信子

研究者氏名	大島信子

URL
所属	藤田医科大学
部署
職名
学位	博士 (医学)(名古屋大学)
J-Global ID	201501000265589428

研究分野

ライフサイエンス / 分子生物学 /

論文

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Two Types of Antibodies Are Induced by Vaccination with A/California/2009pdm Virus: Binding near the Sialic Acid-Binding Pocket and Neutralizing Both H1N1 and H5N1 Viruses

Nobuko Ohshima Ritsuko Kubota-Koketsu Yoshitaka Iba Yoshinobu Okuno Yoshikazu Kurosawa

PLOS ONE 9(2) e87305 2014年2月 [査読有り]

Many people have a history of catching the flu several times during childhood but no additional flu in adulthood, even without vaccination. We analyzed the total repertoire of antibodies (Abs) against influenza A group 1 viruses induced in such a ...

Naturally Occurring Antibodies in Humans Can Neutralize a Variety of Influenza Virus Strains, Including H3, H1, H2, and H5

Nobuko Ohshima Yoshitaka Iba Ritsuko Kubota-Koketsu Yoshizo Asano Yoshinobu Okuno Yoshikazu Kurosawa

JOURNAL OF VIROLOGY 85(21) 11048-11057 2011年11月 [査読有り]

Influenza A viruses are classified into 16 subtypes according to the serotypes of hemagglutinin (HA). It is generally thought that neutralizing antibodies (Abs) are not broadly cross-reactive among HA subtypes. We examined the repertoire of neutra...

Localization of epitopes recognized by monoclonal antibodies that neutralized the H3N2 influenza viruses in man

Jun Okada Nobuko Ohshima Ritsuko Kubota-Koketsu Yoshitaka Iba Sayuri Ota Wakana Takase Tetsushi Yoshikawa Toyokazu Ishikawa Yoshizo Asano Yoshinobu Okuno Yoshikazu Kurosawa

JOURNAL OF GENERAL VIROLOGY 92(Pt 2) 326-335 2011年2月 [査読有り]

Through extensive isolation of neutralizing mAbs against H3N2 influenza viruses representing the in vivo repertoire in a human donor, we examined the relationships between antigenic drift of influenza virus and protective antibodies generated in a...

Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified into three groups with distinct strain specificity: 1968-1973, 1977-1993 and 1997-2003

Jun Okada Nobuko Ohshima Ritsuko Kubota-Koketsu Sayuri Ota Wakana Takase Masachika Azuma Yoshitaka Iba Naoko Nakagawa Tetsushi Yoshikawa Youichi Nakajima Toyokazu Ishikawa Yoshizo Asano Yoshinobu Okuno Yoshikazu Kurosawa

VIROLOGY 397(2) 322-330 2010年2月 [査読有り]

We tried to reveal the strain specificity of neutralizing mAbs against H3N2 influenza viruses in individuals. A large number of B lymphocytes of a pediatrician were collected by apheresis and two Ab libraries were constructed at 2004 and 2007 by u...

HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y

H Tanaka N Ohshima M Ikenoya K Komori F Katoh H Hidaka

CANCER RESEARCH 63(20) 6942-6947 2003年10月 [査読有り]

HMN-176 ((E)-4-([2-N-[4-methoxybenzenesulfonyl]amino]stilbazole]1-oxide) is an active metabolite of HMN-214 ((E)-4-{2-[2-(N-acetyl-N-[4-methoxybenzenesulfonyl]amino)stilbazole]1- -oxide), which has a potent antitumor activity in mouse xenograft mo...