CD22, one of the sialic acid-binding immunoglobulin-like lectins (Siglecs), regulates B lymphocyte signaling via its interaction with glycan ligands bearing the sequence Neu5Ac/Gcα(2→6)Gal. We have developed the synthetic sialoside GSC-718 as a li...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37(1) e22680 2023年1月
Spermatid production is a complex regulatory process in which coordination between hormonal control and apoptosis plays a pivotal role in maintaining a balanced number of sperm cells. Apoptosis in spermatogenesis is controlled by pro-apoptotic and...
Ichiro Hada Akira Shimizu Hiromu Takematsu Yukino Nishibori Toru Kimura Toshiyuki Fukutomi Akihiko Kudo Noriko Ito-Nitta Zentaro Kiuchi Jaakko Patrakka Naoaki Mikami Simon Leclerc Yoshihiro Akimoto Yoshiaki Hirayama Satoka Mori Tomoko Takano Kunimasa Yan
Journal of the American Society of Nephrology : JASN 33(11) 2008-2025 2022年11月
BACKGROUND: The cause of podocyte injury in idiopathic nephrotic syndrome (INS) remains unknown. Although recent evidence points to the role of B cells and autoimmunity, the lack of animal models mediated by autoimmunity limits further research. W...
Biochemical and biophysical research communications 614 198-206 2022年7月
Podocyte damage is a major pathological lesion leading to focal segmental glomerulosclerosis (FSGS). Podocytes damaged by cellular stress undergo hypertrophy to compensate for podocytopenia. It is known that cyclin-dependent kinase inhibitors indu...
Jhon R Enterina Susmita Sarkar Laura Streith Jaesoo Jung Britni M Arlian Sarah J Meyer Hiromu Takematsu Changchun Xiao Troy A Baldwin Lars Nitschke Mark J Shlomchick James C Paulson Matthew S Macauley
Cell reports 38(11) 110512-110512 2022年3月
Germinal centers (GCs) are essential for antibody affinity maturation. GC B cells have a unique repertoire of cell surface glycans compared with naive B cells, yet functional roles for changes in glycosylation in the GC have yet to be ascribed. De...
お知らせ・マニュアル
医療科学部