Takeshi Kitazaki Mikio Oka Yoichi Nakamura Junji Tsurutani Seiji Doi Masa Yasunaga Masaaki Takemura Hikaru Yabuuchi Hiroshi Soda Shigeru Kohno
Lung cancer (Amsterdam, Netherlands) 49(3) 337-343 2005年9月 [査読有り]
Gefitinib (Iressa) is a selective epidermal growth factor receptor tyrosine kinase inhibitor and is used for the treatment of lung cancer. Recently, we discovered that it inhibits the breast cancer resistance protein, which is an ATP-binding casse...
The Journal of pharmacology and experimental therapeutics 311(3) 1032-1037 2004年12月 [査読有り]
Although circulating estrone-3-sulfate is a major precursor of biologically active estrogen, permeation across the plasma membrane is unlikely to occur by diffusion because of the high hydrophilicity of the molecule. The object of this study was t...
OBJECTIVE: Organic cation/carnitine transporter, OCTN1 (SLC22A4) shows a relatively broad tissue distribution and transports organic cations in a pH-dependent manner. However, its physiological role remains to be clarified. To understand the physi...
Biochemical and biophysical research communications 299(3) 410-417 2002年12月 [査読有り]
In the present study, we have cloned the cDNA of ABCC13, a novel ABC transporter, from the cDNA library of adult human placenta. The ABCC13 gene spans approximately 70kb on human chromosome 21q11.2 and consists of 14 exons. The open reading frame ...
Megumi Yoshikawa Hikaru Yabuuchi Asato Kuroiwa Yoji Ikegami Yoshimichi Sai Ikumi Tamai Akira Tsuji Yoichi Matsuda Hisahiro Yoshida Toshihisa Ishikawa
Gene 293(1-2) 67-75 2002年6月 [査読有り]
We have cloned a new mouse ATP-binding cassette (ABC) transporter, Abcg4, from a complementary DNA (cDNA) library of mouse brain. The cloned Abcg4 cDNA encodes a protein consisting of 646 amino acids and including one ATP-binding cassette and six ...
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