Society of Critical Care Medicine 45th Critical Care Congress, Star Research Presentations Awards,Effects of recombinant human thrombomodulin on NETosis in LPS-induced sepsis in miceYu Kato Yasuyo Shimomura Shizuko Nagao Mika Suga Naohide Kuriyama Tomoyuki Nakamura Yoshitaka Hara Osamu Nishida
Society of Critical Care Medicine 44th Critical Care Congress, Top 64 oral presentation,Recombinant human thrombomodulin inhibits neutrophil extracellular traps foramation in vitro、
INTERNATIONAL IMMUNOLOGY 20(6) 729-737 2008年6月 [査読有り]
According to the 'hygiene hypothesis', enhanced microbial exposure due to early childhood infections leads to a reduction of T(h)2-mediated allergic diseases and inflammatory bowel disease. To begin to elucidate the mechanisms underlying...
Yasuyo Shimomura   Atsuhiro Ogawa   Mayumi Kawada   Ken Sugimoto   Emiko Mizoguchi   Hai-Ning Shi   Shiv Pillai   Atul K. Bhan   Atsushi Mizoguchi   
JOURNAL OF EXPERIMENTAL MEDICINE 205(6) 1343-1355 2008年6月 [査読有り]
Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM(+) B cells, but these cells have not been characterized phenotypically or in terms of their developmental origins. We descri...
Background & Aims: Dysregulated host/microbial interactions induce the development of colitis by activating deleterious acquired immune responses. Activation of CD4(+) T cells is mainly induced through signaling machinery associated with immunolog...
Ken Sugimoto   Atsuhiro Ogawa   Emiko Mizoguchi   Yasuyo Shimomura   Akira Andoh   Atul K. Bhan   Richard S. Blumberg   Ramnik J. Xavier   Atsushi Mizoguchi   
JOURNAL OF CLINICAL INVESTIGATION 118(2) 534-544 2008年2月 [査読有り]
Expression of IL-22 is induced in several human inflammatory conditions, including inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate immune cells; however, the role of IL-22 in colitis has not yet been defi...
Background & Aim: T-cell receptor (TCR) gamma delta T cells are an important component of the mucosal immune system and regulate intestinal epithelial homeostasis. Interestingly, there is a significant increase in gamma delta T cells in the inflam...
THERAPEUTIC APHERESIS AND DIALYSIS 15(4) 385-393 2011年8月
The high mobility group box 1 protein (HMGB1) is an alarmin that plays an important role in sepsis and has been recognized as a promising target with a wide therapeutic window; however, no drugs and devices are currently in practical use. We hypot...