Society of Critical Care Medicine 45th Critical Care Congress, Star Research Presentations Awards,Effects of recombinant human thrombomodulin on NETosis in LPS-induced sepsis in miceYu Kato Yasuyo Shimomura Shizuko Nagao Mika Suga Naohide Kuriyama Tomoyuki Nakamura Yoshitaka Hara Osamu Nishida
Society of Critical Care Medicine 44th Critical Care Congress, Top 64 oral presentation,Recombinant human thrombomodulin inhibits neutrophil extracellular traps foramation in vitro、
JOURNAL OF CLINICAL INVESTIGATION 117(3) 605-615 2007年3月 [査読有り]
Granulomas represent a localized inflammatory reaction that is characteristically observed in many inflammatory conditions. However, the mechanisms of granuloma formation have not been fully defined. Herein we , by using experimental models of int...
A Hokama   E Mizoguchi   K Sugimoto   Y Shimomura   Y Tanaka   M Yoshida   ST Rietdijk   YP de Jong   SB Snapper   C Terhorst   RS Blumberg   A Mizoguchi   
IMMUNITY 20(6) 681-693 2004年6月 [査読有り]
Inflammatory bowel disease is an immune-mediated intestinal inflammatory condition that is associated with an increase in autoantibodies that bind to epithelial cells. However, it is unknown whether the epithelial cell-derived products that are re...
THERAPEUTIC APHERESIS AND DIALYSIS 15(4) 385-393 2011年8月
The high mobility group box 1 protein (HMGB1) is an alarmin that plays an important role in sepsis and has been recognized as a promising target with a wide therapeutic window; however, no drugs and devices are currently in practical use. We hypot...