Pituitary organoids are promising graft sources for transplantation in treatment of hypopituitarism. Building on development of self-organizing culture to generate pituitary-hypothalamic organoids (PHOs) using human pluripotent stem cells (hPSCs),...
The hypothalamus is comprised of heterogenous cell populations and includes highly complex neural circuits that regulate the autonomic nerve system. Its dysfunction therefore results in severe endocrine disorders. Although recent experiments have ...
Frontiers in Endocrinology 13 941166 2022年7月 [査読有り]
Human stem cell-derived organoid culture enables the in vitro analysis of the cellular function in three-dimensional aggregates mimicking native organs, and also provides a valuable source of specific cell types in the human body. We previously es...
Yu Kodani   Miho Kawata   Hidetaka Suga   Yoko S. Kaneko   Akira Nakashima   Toshiki Kameyama   Kanako Saito   Hiroshi Nagasaki   
eNeuro 9(2) ENEURO.0442-21.2022 2022年4月 [査読有り]
Hypothalamic melanin-concentrating hormone (MCH) neurons are important regulators of multiple physiological processes, such as sleep, feeding, and memory. Despite the increasing interest in their neuronal functions, the molecular mechanism underly...
Journal of Neural Transmission (Vienna, Austria : 1996) 127(12) 1631-1640 2020年8月 [査読有り]
5'-Nucleotidase domain-containing protein 2 (NT5DC2) has been revealed by genome-wide association studies (GWAS) as a gene implicated in neuropsychiatric disorders related to the abnormality of dopamine (DA) activity in the brain. Based on its ami...
Y. S. Kaneko   A. Nakashima   K. Mori   H. Nagasaki   Y. Kodani   I. Nagatsu   T. Nagatsu   A. Ota