PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 469(10) 1335-1347 2017年10月 [査読有り]
FMRFamide-gated Na+ channel (FaNaC) is a member of the DEG/ENaC family. Amino acid sequence of the second transmembrane region (TM2) of FaNaC is quite similar to that of the acid-sensing ion channels (ASIC) of the same family. In the upper part of...
Akira Nakashima   Syuhei Ohnuma   Yu Kodani   Yoko S. Kaneko   Hiroshi Nagasaki   Toshiharu Nagatsu   Akira Ota   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 472(4) 598-602 2016年4月 [査読有り]
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. However, the intracellular stability determined by the degradation...
TEP (Thais excitatory peptide)-1 and TEP-2 are molluscan counterparts of annelidan GGNG-peptides, identified in a neogastropod, Thais clavigera (Morishita et al., 2006). We have cloned two cDNAs encoding TEP-1 and TEP-2 precursor protein, respecti...
Yoko S. Kaneko   Takeshi Takayanagi   Hiroshi Nagasaki   Yu Kodani   Akira Nakashima   Keiji Mori   Atsushi Suzuki   Mitsuyasu Itoh   Kazunao Kondo   Toshiharu Nagatsu   Miyuki Ota   Akira Ota   
JOURNAL OF NEURAL TRANSMISSION 122(6) 757-772 2015年6月 [査読有り]
We previously showed that aripiprazole increases intracellular NADPH and glucose-6-phosphate dehydrogenase mRNA in PC12 cells. Aripiprazole presumably activates a system that concurrently detoxifies reactive oxygen species and replenishes NADPH. N...
Yoko S. Kaneko   Akira Ota   Akira Nakashima   Hiroshi Nagasaki   Yu Kodani   Keiji Mori   Toshiharu Nagatsu   
JOURNAL OF NEURAL TRANSMISSION 122(2) 187-199 2015年2月 [査読有り]
We previously reported that an optimal dose of lipopolysaccharide (LPS) markedly extends the lifespan of murine primary-cultured microglia by suppressing cell death pathways. In this study, we investigated the effects of LPS pretreatment on UV lig...