Takayanagi T   Kaneko YS   Nagasaki H   Kodani Y   Nakashima A   Mori K   Suzuki A   Itoh M   Kondo K   Nagatsu T   Ota M   Ota A   
Fujita Medical Journal 1(1) 1-5 2015年 [査読有り]
Objectives: According to our previous work, aripiprazole exerted a protective effect on hydrogen peroxide (H2O2)-treated PC12 cells; haloperidol did not. Because aripiprazole has distinct affinities to a set of neurotransmitter receptor subtypes, ...
Nagasaki H   Kodani Y   Suga H   
Interdisciplinary Information Sciences 21(3) 261-266 2015年 [査読有り]
Recently, various hypothalamic neurons have been successfully engineered from pluripotent stem cells, including mouse and human embryonic stem cells. Because pluripotent cells need to undergo stepwise changes during organogenesis, developmental an...
JOURNAL OF PHYSIOLOGICAL SCIENCES 64(2) 141-150 2014年3月 [査読有り]
The FMRFamide-gated Na+ channel (FaNaC) is a unique peptide-gated sodium channel and a member of the epithelial sodium channel/degenerin family. Previous studies have shown that an aspartate residue (Asp(552)) in the second transmembrane domain is...
Hiroshi Nagasaki   Akira Nakashima   Yoko S. Kaneko   Yu Kodani   Takeshi Takayanagi   Mitsuyasu Itoh   Kazunao Kondo   Toshiharu Nagatsu   Yoji Hamada   Miyuki Ota   Akira Ota   
JOURNAL OF NEURAL TRANSMISSION 121(1) 91-103 2014年1月 [査読有り]
In aripiprazole-treated PC12 cells, we previously showed that the mitochondrial membrane potential (Delta psi(m)) was rather increased in spite of lowered cytochrome c oxidase activity. To address these inconsistent results, we focused the NADPH g...
Akira Nakashima   Yoko S. Kaneko   Yu Kodani   Keiji Mori   Hiroshi Nagasaki   Toshiharu Nagatsu   Akira Ota   
Advances in Pharmacology 68 3-11 2013年 [査読有り]
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is a key protein involved in the pathogenesis of neurodegenerative diseases such as Parkinson's disease. Elucidation of the mechanisms regulating the synthe...