Taniguchi S   Ninomiya K   Kushima I   Saito T   Shimasaki A   Sakusabe T   Momozawa Y   Kubo M   Kamatani Y   Ozaki N   Ikeda M   Iwata N   
Psychiatry and clinical neurosciences 74(1) 35-39 2019年8月 [査読有り]
Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size. We conducted a GWAS in t...
Psychiatry and clinical neurosciences 72(4) 245-254 2018年4月 [査読有り]
AIM: Schizophrenia (SZ) and bipolar disorder (BD) have been known to share genetic and environmental risk factors, and complex gene-environmental interactions may contribute to their pathophysiology. In contrast to high genetic overlap between SZ ...
Psychiatry and Clinical Neurosciences 72(2) 52-63 2018年2月 [査読有り]
Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide a...
統合失調症の病態は依然として不明のままであり、現在に至るまでさまざまな切り口から多くの研究がなされてきた。近年、全ゲノム関連研究(genome-wide association study;GWAS)は疾患感受性遺伝子同定に大きく寄与し、病態研究の新たなヒントを与えている。本稿では統合失調症GWASの成果について触れる。(著者抄録)