Objective The objective of this study was to estimate the humoral immune response evaluated by immunoglobulin G (IgG) against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD-IgG) following the th...
Nanaka Morita Masato Hoshi Hiroyuki Tezuka Tatsuya Ando Sayaka Yoshida Fumiaki Sato Hiroyuki Yokoi Hiroyasu Ito Kuniaki Saito
ImmunoHorizons 7(5) 353-363 2023年5月
Sepsis is a systemic inflammatory disease caused by a bacterial infection that leads to severe mortality, especially in elderly patients, because of an excessive immune response and impaired regulatory functions. Antibiotic treatment is widely acc...
Tatusya Ando Daisuke Ito Kazuya Shiogama Yasuhiro Sakai Masato Abe Takayasu Ideta Ayumu Kanbe Masahito Shimizu Hiroyasu Ito
Biochemical and Biophysical Research Communications 648 44-49 2023年3月 [査読有り]
A previous study revealed that treatment with the anticoagulant heparin attenuated concanavalin A (ConA)-induced liver injury. The administration of spermidine (SPD) increased urokinase-type plasminogen activator (uPA) levels in the serum. uPA is ...
Indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing intracellular enzyme of the L-kynurenine pathway, causes preneoplastic cells and tumor cells to escape the immune system by inducing immune tolerance; this mechanism might be associated ...
The immunomodulatory effects of indoleamine 2,3-dioxygenase (IDO) are ascribed to its ability to catalyze the breakdown of the L-tryptophan along the L-kynurenine pathway. Because blasts from patients with acute myeloid leukemia (AML) express IDO,...
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