Nanaka Morita Masato Hoshi Hiroyuki Tezuka Tatsuya Ando Sayaka Yoshida Fumiaki Sato Hiroyuki Yokoi Hiroyasu Ito Kuniaki Saito
ImmunoHorizons 7(5) 353-363 2023年5月
Sepsis is a systemic inflammatory disease caused by a bacterial infection that leads to severe mortality, especially in elderly patients, because of an excessive immune response and impaired regulatory functions. Antibiotic treatment is widely acc...
The partial loss of liver due to liver transplantation or acute liver failure induces rapid liver regeneration. Recently, we reported that the selective inhibition of indoleamine 2,3‑dioxygenase (Ido) 1 promotes early liver regeneration. However, ...
Kyoka Yamazaki Masato Hoshi Hiroyuki Tezuka Nanaka Morita Masaya Hirayama Fumiaki Sato Sayaka Yoshida Kuniaki Saito
Oncology reports 47(6) 2022年6月
Various cancer cells require massive amounts of glucose as an energy source for their dysregulated growth. Although D‑allose, a rare sugar, inhibits tumor cell growth via inhibition of glucose uptake, a few cells can survive after treatment. Howev...
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy that is the most common type of lymphoma in Japan. Previous studies have demonstrated that patients with DLBCL have a poor prognosis due to increased levels of...
Genki Mizuno Masato Hoshi Kentaro Nakamoto Masayo Sakurai Kazuko Nagashima Takashi Fujita Hiroyasu Ito Tadayoshi Hata
Clinical chemistry and laboratory medicine 59(9) 1547-1553 2021年8月
OBJECTIVES: The microscopic examination of hematuria, a cardinal symptom of glomerulonephritis (GN), is time-consuming and labor-intensive. As an alternative, the fully automated urine particle analyzer UF-5000 can interpret the morphological info...
Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme in the kynurenine pathway that converts l-tryptophan to l-kynurenine. Transient forebrain ischemia initiates a series of cellular events that lead to the delayed neuronal degeneration o...
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